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- bs-2132R
- 2026年10月13日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2132R |
| 英文名称 | Angiotensin II type 1A receptor Rabbit pAb |
| 中文名称 | 血管紧张素Ⅱ1A型受体抗体 |
| 英文别名 | AGTR1; Agtr1a; AT1; AT1A; AT1AR; Type 1 angiotensin II receptor; AGTR1_HUMAN; AGTR1B; AT2R1; AT2R1B. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Angiotensin II type 1A receptor |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 41 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Cellular metabolic process Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic growth factors Cardiovascular > Blood > Blood Pressure regulation Metabolism > Types of disease > Cancer |
| 亚基 | Interacts with MAS1 (Probable). Interacts with ARRB1. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Liver, lung, adrenal and adrenocortical adenomas. |
| 翻译后修饰 | C-terminal Ser or Thr residues may be phosphorylated. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
_x000D_ Lane 1: Liver (Mouse) Lysate at 40 ug
_x000D_ Lane 2: Heart (Mouse) Lysate at 40 ug
_x000D_ Lane 3: Placenta (Mouse) Lysate at 40 ug
_x000D_ Lane 4: Kidney (Mouse) Lysate at 40 ug
_x000D_ Lane 5: Embryo (Mouse) Lysate at 40 ug
_x000D_ Lane 6: Cerebrum (Mouse) Lysate at 40 ug
_x000D_ Lane 7: NIH/3T3 (Mouse) cell Lysate at 30 ug
_x000D_ Lane 8: Liver (Rat) Lysate at 40 ug
_x000D_ Lane 9: Heart (Rat) Lysate at 40 ug
_x000D_ Lane 10: Kidney (Rat) Lysate at 40 ug
_x000D_ Lane 11: Cerebrum (Rat) Lysate at 40 ug
_x000D_ Lane 12: Embryo (Rat) Lysate at 40 ug
_x000D_ Primary: Anti-Angiotensin II type 1A receptor (bs-2132R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 43 kD
_x000D_ Observed band size: 46 kD
_x000D_ A549(Human) Cell Lysate at 430 ug
_x000D_ Primary: Anti-Angiotensin II type 1A receptor (bs-2132R) at 1/500 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 41 kD
_x000D_ Observed band size: 41/51 kD
_x000D_ Liver (Mouse) Lysate at 40 ug
_x000D_ Lung (Mouse) Lysate at 40 ug
_x000D_ Adrenal gland (Rat) Lysate at 40 ug
_x000D_ Primary: Anti-Angiotensin II type 1A receptor (bs-2132R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 41 kD
_x000D_ Observed band size: 56 kD
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文献和实验[IF=5.6] Wenjing Zhang. et al. Antihypertensive Peptide ENWAAL Derived from Coix Glutelin and Its Effect on the Expression of SHR Renin–Angiotensin System. BIOMOLECULES. 2026 Jun;16(6):888 WB Rat
[IF=2.03] Liu, Junjun, et al. "Differential effects of angiotensin II receptor blockers on Aβ generation." Neuroscience Letters (2014). WB ="Mouse"
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
GE Healthcare Benzamidine Sepharose™ 6B is p-aminobenzamidine covalently attached to Sepharose 6B by the epoxy coupling method. p-Aminobenzamidine (PAB), is a synthetic inhibitor of trypsin-like serine protease. Trypsin and trypsin
Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
.g., Sigma) 50 mg/ml bis‐sulfosuccinimdylsuberate (BS3 ;Pierce, cat. no. PI 21580) in dimethylsulfoxide (DMSO) 5 mg/ml
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