Angiotensin II type 1A receptor Rabbit pAb(bs-2132R)-50ul/100ul/200ul
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Angiotensin II type 1A recepto

r Rabbit pAb(bs-2132R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-2132R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-2132R
    英文名称Angiotensin II type 1A receptor Rabbit pAb
    中文名称血管紧张素Ⅱ1A型受体抗体
    英文别名AGTR1; Agtr1a; AT1; AT1A; AT1AR; Type 1 angiotensin II receptor; AGTR1_HUMAN; AGTR1B; AT2R1; AT2R1B.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Angiotensin II type 1A receptor
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量41 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Cellular metabolic process

    Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic growth factors

    Cardiovascular > Blood > Blood Pressure regulation

    Metabolism > Types of disease > Cancer

    亚基Interacts with MAS1 (Probable). Interacts with ARRB1.
    亚细胞定位Cell membrane; Multi-pass membrane protein.
    组织特异性Liver, lung, adrenal and adrenocortical adenomas.
    翻译后修饰C-terminal Ser or Thr residues may be phosphorylated.
    相似性Belongs to the G-protein coupled receptor 1 family.
    功能Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq].

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    Angiotensin II type 1A recepto
    P‌‌araformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Angiotensin II type 1A receptor) Polyclonal Antibody, Unconjugated (bs-2132R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    Angiotensin II type 1A recepto
    Sample:
    Lane 1: Liver (Mouse) Lysate at 40 ug
    Lane 2: Heart (Mouse) Lysate at 40 ug
    Lane 3: Placenta (Mouse) Lysate at 40 ug
    Lane 4: Kidney (Mouse) Lysate at 40 ug
    Lane 5: Embryo (Mouse) Lysate at 40 ug
    Lane 6: Cerebrum (Mouse) Lysate at 40 ug
    Lane 7: NIH/3T3 (Mouse) cell Lysate at 30 ug
    Lane 8: Liver (Rat) Lysate at 40 ug
    Lane 9: Heart (Rat) Lysate at 40 ug
    Lane 10: Kidney (Rat) Lysate at 40 ug
    Lane 11: Cerebrum (Rat) Lysate at 40 ug
    Lane 12: Embryo (Rat) Lysate at 40 ug
    Primary: Anti-Angiotensin II type 1A receptor (bs-2132R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 43 kD
    Observed band size: 46 kD
    Angiotensin II type 1A recepto
    Sample:
    A549(Human) Cell Lysate at 430 ug
    Primary: Anti-Angiotensin II type 1A receptor (bs-2132R) at 1/500 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 41 kD
    Observed band size: 41/51 kD
    Angiotensin II type 1A recepto
    Sample:
    Liver (Mouse) Lysate at 40 ug
    Lung (Mouse) Lysate at 40 ug
    Adrenal gland (Rat) Lysate at 40 ug
    Primary: Anti-Angiotensin II type 1A receptor (bs-2132R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 41 kD
    Observed band size: 56 kD
    Angiotensin II type 1A recepto
    P‌‌araformaldehyde-fixed, paraffin embedded (rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Angiotensin II type 1A receptor) Polyclonal Antibody, Unconjugated (bs-2132R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    图标文献和实验
    该产品被引用文献

    [IF={{ 2.03 }}] {Liu, Junjun, et al. "Differential effects of angiotensin II receptor blockers on Aβ generation." Neuroscience Letters (2014).} {WB} {="Mouse"}

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    文献支持
    Angiotensin II type 1A receptor Rabbit pAb(bs-2132R)-50ul/100ul/200ul
    ￥1180 - 2800