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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1138R |
| 英文名称 | Somatostatin Receptor 2 Rabbit pAb |
| 中文名称 | 生长抑素受体2抗体 |
| 英文别名 | somatostatin receptor 2; Somatostatin receptor type 2; SRIF1; SS2R; SST2; SSTR2; SRIF-1; SS-2-R; SS2-R; SSR2_HUMAN. |
| 产品应用 | WB=1:500-2000, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, GuineaPig) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SSTR2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 41 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Hormone biosynthesis Metabolism > Pathways and Processes > Endocrine metabolism > Hormone biosynthesis Neuroscience > Neurology process > Neuroendocrinology > GH Regulation Neuroscience > Neurotransmission > Receptors / Channels > GPCR > More GPCR Neuroscience > Neurotransmitter > Neuropeptides > Hormones |
| 亚基 | The C-terminus interacts with SHANK1 PDZ domain. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Cerebrum and kidney. In lesser amounts in jejunum, colon and liver. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Somatostatin is a tetradecapeptide that is widely distributed in the body and is one of five receptor subtypes termed SSTr1-. These receptors function in the regulation of numerous phsiological processes such as the secretion of insulin, glucagon and growth hormone as wel as cell growth induced by neuronal excitation in both the central and peripheral nervous systems. Somatostatin receptos are activated via sonatostatin secreted by nerve and endocrine cells. Somatostatin Receptor 2 (SSR2), along with SSR1, is expressed at the highest levels in the stomach and jejunum, cerebrum and kidney, respectively. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 6.792 }}] {Zhao D et al. PCB52 exposure alters the neurotransmission ligand-receptors in male offspring and contributes to sex-specific neurodevelopmental toxicity. Environ Pollut.2020 Sep;264:114715.} {WB} {Rat}
[IF={{ 2.22 }}] {Ruan, Ming, et al. "Attenuation of stress-induced gastrointestinal motility disorder by gentiopicroside, from Gentiana macrophylla Pall." Fitoterapia(2015).} {WB} {="Rat"}
[IF={{ 1.399 }}] {Jiuxiu Jiet al. The effect of miR‐10b on growth hormone in pituitary cells of Yanbian yellow cattle by somatostatin receptor 2. Anim Sci J . Jan-Dec 2020;91(1):e13420.} {WB} {yellow cattle}
[IF={{ 0.88 }}] {Sakai, Kosei, et al. "Alteration of somatostatin receptor 2 expression in canine mammary gland tumor." Journal of Veterinary Medical Science 0 (2015).} {IHC} {="Dog"}
, Algermissen, B. et al. 3. Purification of rabbit liver aldehyde oxidase by affinity chromatography on benzamidine Sepharose 6B. J. Chromatogr. (1989), 475 363-72, Stell, J. G. P. et al. 4. The Crystal Structure of a T Cell Receptor in Complex
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