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FGF23 | Phosphatonin Rabbit pA

b(bs-5768R)-50ul/100ul/200ul

价格￥1180 - 2800

品牌Bioss
货号bs-5768R
更新日期2026年10月13日

10 年钻石会员

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规格：
50ul/100ul/200ul

规格：	50ul	产品价格：	￥1180.0
规格：	100ul	产品价格：	￥1980.0
规格：	200ul	产品价格：	￥2800.0

产品编号	bs-5768R
英文名称	FGF23 Rabbit pAb
中文名称	成纤维细胞生长因子23抗体
英文别名	ADHR; FGF-23; Fgf23; FGF 23; FGF23_HUMAN; Fibroblast growth factor 23; Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 precursor; HPDR2; HYPF; Phosphatonin; PHPTC; Tumor derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor.
产品应用	WB=1:500-2000 Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
交叉反应	Human, Rat (Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, GuineaPig)
抗体来源	Rabbit
免疫原	KLH conjugated synthetic peptide derived from human Fibroblast growth factor 23
亚型	IgG
性状	Liquid
纯化方法	affinity purified by Protein A
克隆类型	Polyclonal
理论分子量	27 kDa
浓度	1mg/ml
储存液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
亚基	Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors._x000D_
亚细胞定位	Secreted. Note=Secretion is dependent on O-glycosylation._x000D_
组织特异性	Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts)._x000D_
翻译后修饰	Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases. _x000D_ O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23._x000D_
相似性	Belongs to the heparin-binding growth factors family._x000D_
功能	Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization._x000D_
保存条件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料	This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]

应用	推荐稀释比例
{WB}	{1:500-2000}

Sample:
_x000D_ bone (rat)Lysate at 40 ug
_x000D_ Primary: Anti- MRPL32 (bs-5768R)at 1/300 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 27kD
_x000D_ Observed band size: 27kD
_x000D_

Sample:
_x000D_ Lane 1: Bone (Rat) Lysate at 40 ug
_x000D_ Lane 2: Cerebrum (Rat) Lysate at 40 ug
_x000D_ Primary:
_x000D_ Anti-FGF23 (bs-5768R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 30/32 kD
_x000D_ Observed band size: 30 kD

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