COL18A1 | Endostatin Rabbit pAb(bs-0547R)-50ul/100ul/200ul产品图
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COL18A1 | Endostatin Rabbit pA

b(bs-0547R)-50ul/100ul/200ul
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  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-0547R
    英文名称Endostatin Rabbit pAb
    中文名称内皮抑素/内皮他丁抗体
    英文别名Collagen XV alpha 1; alpha 1 collagen type 18(XVIII)(COL18A1); alpha 1 type XVIII collagen; COL18A1; Collagen alpha 1(XVIII) chain; Collagen type XVIII alpha 1; FLJ27325; KNO; MGC74745; COL18A1; COIA1_HUMAN; Antiangiogenic agent; COIA1_HUMAN; COL15A1; COL18A1; Collagen alpha 1(XV) chain; Collagen alpha-1(XV) chain; Collagen type XV proteoglycan; Collagen type XVIII alpha 1; Collagen XV, alpha 1 polypeptide; Collagen, type XV, alpha 1; Endostatin; Endostatin XV; FLJ34914; FLJ38566; KNO1; KS; Multi functional protein MFP; OTTHUMP00000021782; OTTHUMP00000115472; OTTHUMP00000115473.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse (Rat)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Endostatin
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量20/190 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic inhibitory factors

    Cardiovascular > Angiogenesis > Inhibitors

    Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Collagen

    亚细胞定位Secreted, extracellular space, extracellular matrix.
    组织特异性Present in multiple organs with highest levels in liver, lung and kidney.
    翻译后修饰Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
    相似性Belongs to the multiplexin collagen family.
    _x000D_ Contains 1 FZ (frizzled) domain.
    _x000D_ Contains 1 TSP N-terminal (TSPN) domain.
    功能COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube._x000D_
    Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Sample:
    _x000D_ Liver (Mouse) Lysate at 40 ug
    _x000D_ Primary: Anti-Endostatin (bs-0547R) at 1/500 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 20/190 kD
    _x000D_ Observed band size: 155 kD
    产品细节图片2
    Tissue/cell: human kidney carcinoma; 4% P‌‌araformaldehyde-fixed and paraffin-embedded;
    _x000D_ Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
    _x000D_ Incubation: Anti-Endostatin Polyclonal Antibody, Unconjugated(bs-0547R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
    _x000D_

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    COL18A1 | Endostatin Rabbit pAb(bs-0547R)-50ul/100ul/200ul
    ￥1180 - 2800