Sample:
Lane 1: Human HepG2 cell lysates
Lane 2: Human U-2 OS cell lysates
Lane 3: Human HeLa cell lysates
Lane 4: Human Jurkat cell lysates
Primary: Anti-SOCS1 (bs-0113R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 23 kDa
Observed band size: 25 kDa
- ￥1180 - 2800
- Bioss
- bs-0113R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-0113R |
| 英文名称 | SOCS1 Rabbit pAb |
| 中文名称 | 细胞因子信号传导抑制蛋白1抗体 |
| 英文别名 | CISH 1; CISH1; Cytokine Inducible SH2 Protein 1; JAB; JAK Binding Protein; Janus kinase binding protein; SOCS 1; SOCS1; SOCS-1; SSI 1; SSI1; STAT Induced STAT Inhibitor 1; Supressor of cytokine Signalling 1; TEC Interacting Protein 3; TIP 3; TIP3; SOCS1_HUMAN. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Socs 1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 23 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > STATs Immunology > Immune System Diseases > Autoimmune Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus Signal Transduction > Adapters > Cytoplasmic |
| 亚基 | Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV. Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts (via SH2 domain and SOCS box) with TRIM8. Interacts with AXL, CUL2 and FGFR3. Interacts with INSR. |
| 亚细胞定位 | Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3. |
| 组织特异性 | Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes. |
| 相似性 | Contains 1 SH2 domain. Contains 1 SOCS box domain. |
| 功能 | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor(LIF). Regulates interferon-gamma mediated sensory neuron survival. Implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. High expression in thymus. Lower expression in lung and spleen. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验该产品被引用文献
[IF={{ 8.786 }}] {Xiangnan Hao. et al. LNA-anti-miR-150 alleviates renal interstitial fibrosis by reducing pro-inflammatory M1/M2 macrophage polarization. FRONT IMMUNOL. 2022; 13: 913007} {IHC} {Mouse}
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= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
分装 F0110 干扰素-r 受体 (IFN-rR) ELISA 48T/96T 1200/2000 进口分装 F0111 抗干扰素- a 抗体 (anti-IFN- a b) ELISA 48T/96T 1200/2000 进口分装 F0112 胰岛素样生长因子-1 (IGF-1) ELISA 48T/96T 1500/2500 进口分装 F0113 胰岛素样生长因子-2 (IGF-2) ELISA 48T/96T 1500/2500
分装 F0110 干扰素-r 受体 (IFN-rR) ELISA 48T/96T 1200/2000 进口分装 F0111 抗干扰素- a 抗体 (anti-IFN- a b) ELISA 48T/96T 1200/2000 进口分装 F0112 胰岛素样生长因子-1 (IGF-1) ELISA 48T/96T 1500/2500 进口分装 F0113 胰岛素样生长因子-2 (IGF-2) ELISA 48T/96T 1500/2500
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SOCS1 Rabbit pAb(bs-0113R)-50ul/100ul/200ul
￥1180 - 2800
