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- 详细信息
- 文献和实验
- 技术资料
- 克隆性:
多克隆
- 抗体英文名:
SOCS1 Antibody,CIS1 ,CISH1,JAB,JAK binding protein,SOCS-1,SOCS1 ,SSI-1,SSI1,TIP3
- 规格:
100 ug
产品名称:SOCS1抗体|SOCS1 Antibody,CIS1 ,CISH1,JAB,JAK binding protein,SOCS-1,SOCS1 ,SSI-1,SSI1,TIP3
【产品形式】:艾美捷为您提供的SOCS1 抗体产品为100 ug 无色溶液,其浓度为0.5 mg/ml,溶解于包含有30%甘油, 0.5% BSA, 0.01%硫柳汞的PBS (pH 7.2)缓冲液中.请将该SOCS1 抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.
【背景资料】:The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins that regulate responses to cytokines. SOCS1 suppresses dendritic cell and T cell hyperactivation in response to cytokine signaling by inhibiting the JAK tyrosine kinase. JAK tyrosine kinase activity is important for type I and II cytokine receptors to initiate signaling, and its activity is inhibited by direct binding of SOCS1 to the catalytic domain of the kinase. SOCS1 also has E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome.
BioVision的公司总部在美丽的旧金山湾地区,它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有 卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品,以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代 谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理, 艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
点击:SOCS1抗体,查看更详细产品说明,更多应用、储存、价格、货期等信息请致电400-6800-868垂询BioVision中国区域授权总代理艾美捷科技有限公司。
关键词:SOCS,SOCS1抗体
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文献和实验【信息】The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
. MAL is required to recruit MyD88 to TLR2 and TLR4. It is membrane associated through a phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2)-binding domain and is subject to regulation by Bruton's tyrosine kinase and SOCS1 (suppressor of cytokine
for instance is part of the early inducible PRG cluster and down modulation occurs together with the other genes before onset of SRG expression. It is believed that feedback inhibition of JAK/STAT signaling by SOCS1 represses transcriptome modulation of IFN
Identifying Functional Annotation for Noncoding Genomic Sequences
Figure 1.10.1 Example of data derived by browsing an intergenic region between CLEC16A and SOCS1 that spans several variants associated with altered risk for multiple sclerosis (Zuvich et al., ). Panels A, B , and C show successively “zoomed
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