Sample:
Lane 1: TIMP-1 fusion protein (bs-43009P) 0.2ug
Primary: Anti-TIMP-1(bs-0415R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 21kDa
Observed band size: 25kDa
- ￥1180 - 2800
- Bioss
- bs-0415R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-0415R |
| 英文名称 | TIMP-1 Rabbit pAb |
| 中文名称 | 金属蛋白酶组织抑制因子-1抗体 |
| 英文别名 | Clgi; Collagenase inhibitor; EPA; EPO; Erythroid Potentiating Activity; Fibroblast collagenase inhibitor; FLJ90373; HC; Human Collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; OTTHUMP00000023214; TIMP 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP1 protein; Tissue Inhibitor of Metalloproteinase 1; Tissue inhibitor of metalloproteinases; Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TIMP-1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 21 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Invasion/microenvironment > Angiogenesis > ECM enzymes > TIMPs Cancer > Invasion/microenvironment > ECM > Extracellular matrix > TIMPs Cardiovascular > Angiogenesis > Adhesion / ECM > Matrix Metalloproteinases > TIMP Cell Biology > Proteolysis / Ubiquitin > Protease inhibitors > Metalloprotease inhibitors > TIMPs Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > TIMP1 / TIMP2 |
| 亚细胞定位 | Secreted. |
| 翻译后修饰 | The activity of TIMP1 is dependent on the presence of disulfide bonds. |
| 相似性 | Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. |
| 功能 | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF={{ 7.4 }}] {Shimoji Kiyofumi. et al. Hypoxia-inducible factor 1α modulates interstitial pneumonia-mediated lung cancer progression. J TRANSL MED. 2023 Dec;21(1):1-19} {IHC} {Mouse}
[IF={{ 6.543 }}] {Yang Lili. et al. Elucidating the Novel Mechanism of Ligustrazine in Preventing Postoperative Peritoneal Adhesion Formation. Oxid Med Cell Longev. 2022;2022:9226022} {WB} {Rat,Human}
[IF={{ 5.7 }}] {Yang Liu. et al. Paeoniflorin Coordinates Macrophage Polarization and Mitigates Liver Inflammation and Fibrogenesis by Targeting the NF-κB/HIF-1α Pathway in CCl4-Induced Liver Fibrosis. AM J CHINESE MED. 2023 Jun 14} {WB} {Mouse,Rat}
[IF={{ 5.5 }}] {Dina Abdalla Arida. et al.Comparative efficacy of conventional and nanoparticulate losartan in mitigating oxidative stress and fibrosis induced by CCl4 in rat testes.Journal of Hazardous Materials Advances.} {IHC} {}
[IF={{ 5.223 }}] {Choirul Anwar. et al. Molecular mechanisms of Agardhiella subulata attenuates hepatic fibrosis by modulating hepatic stellate cell activation via the reduction of autophagy. J FUNCT FOODS. 2022 Sep;96:105226} {WB} {Rat}
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TIMP-1 Rabbit pAb(bs-0415R)-50ul/100ul/200ul
￥1180 - 2800
