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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 规格： | 200ug | 产品价格： | ￥5600.0 |
| 产品编号 | bsm-33143M |
| 英文名称 | Fibronectin/FN1 Mouse mAb |
| 中文名称 | 纤维连接蛋白单克隆抗体 |
| 英文别名 | CIG; Cold insoluble globulin; DKFZp686F10164; DKFZp686H0342; DKFZp686I1370; DKFZp686O13149; ED B; ED-B; fibronectin 1; FINC; FN 1; FN; FN1; FNZ; GFND; GFND2; LETS; Migration stimulating factor; MSF; Transformation sensitive protein; FINC_HUMAN; Fibronectin; Cold-insoluble globulin; Ugl-Y3. |
| 产品应用 | WB=1:1000-2000 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Mouse |
| 免疫原 | KLH conjugated synthetic peptide derived from human Fibronectin/FN1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein G |
| 克隆类型 | Monoclonal |
| 理论分子量 | 259 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Extracellular matrix Cardiovascular > Angiogenesis > Adhesion / ECM > Extracellular Matrix Developmental Biology > Lineage specification > Ectoderm Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Fibronectin Stem Cells > Lineage Markers > Ectoderm Stem Cells > Mesenchymal Stem Cells > Osteogenesis Stem Cells > Neural Stem Cells > Extracellular |
| 亚基 | Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7. Interacts with COMP. Interacts with S.aureus fnbA. Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth. Interacts with FST3. |
| 亚细胞定位 | Secreted, extracellular space, extracellular matrix. |
| 组织特异性 | Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine. |
| 翻译后修饰 | Sulfated._x000D_
It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated._x000D_ Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers)._x000D_ Phosphorylation sites are present in the extracellular medium._x000D_ Proteolytic processing produces the C-terminal NC1 peptide, anastellin. |
| 相似性 | Contains 12 fibronectin type-I domains. Contains 2 fibronectin type-II domains. Contains 16 fibronectin type-III domains. |
| 功能 | Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape._x000D_
Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | bs-0666P is a synthetic peptide derived from human Fibronectin. This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:1000-2000} |
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文献和实验[IF=8.5] Kairui Duan. et al. Human serum albumin-based cryogels as a biomimetic platform for 3D co-culture and drug-induced liver injury prediction. INT J BIOL MACROMOL. 2025 Sep;321:146376 IF Human
[IF=8.2] Xiaoyin Guo. et al. Mechanism underlying the role of integrin α3β1 in adhesive dysfunction between thyroid cells induced by diesel engine exhaust particles. SCI TOTAL ENVIRON. 2024 Oct;947:174535 WB Mouse
组学方法的主要工具。正在采取巨大努力来使重组蛋白的表达和纯化自动化。已经在大肠杆菌和杆状病毒系统中发展了生产大量平行重组蛋白的微小表达系统。已经生产了高密度融合蛋白的微阵列来筛选抗体特异性，也已经生产了高密度单链抗体文库分析来确定适当的抗原。 Table 1.Classes of capture molecules Capture molecules Source Technique Refs mAb Mouse Hybridoma Reviewed in [42,43
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