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文献和实验Pathways Implicated in Stem Cell Migration: The SDF-1/CXCR4 Axis
The hallmark of hematopoietic stem and progenitor cells (HSPCs) is their motility, which is essential for their function, such as recruitment upon demand. Stromal Derived Factor-1 (SDF-1, CXCL12) and its major receptor CXCR4 play major roles
【进展|热点】Nature Immunology：骨髓基质细胞通过细胞间接触分泌SDF-1
by regulating the nuclear localization of the transcription factor Sp1. We suggest that BMSCs form a dynamic syncytium via connexin gap junctions that regulates CXC12 secretion and the homeostasis of hematopoietic stem cells.文章简介：CXCL12（SDF-1）对造血干细胞和前体细胞的功能发育至关
Biological Role of the CXCR4-SDF-1 Axis in Normal Human Hematopoietic Cells
Stromal-derived factor (SDF)-1, an α-chemokine that binds to G protein-coupled seven transmembrane-spanning receptor, CXCR4, plays an important and unique role in regulating the trafficking of normal hematopoietic stem/progenitor cells
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