A-M Systems电生理系列产品

A-M Systems是美国知名科研仪器制造商，其产品以优秀的性能及合理的价格深受广大科研人员欢迎并在Science, Nature, Neuroscience等权威期刊上引用。产品覆盖膜片钳放大器、细胞内/外放大器、刺激信号发生器、信号采集等电生理实验必备仪器及其配件。

膜片钳放大器
Model 2400 膜片钳放大器
产品特点：
l 全功能膜片钳，实现全细胞记录及和膜片记录
l 可切换的双阻反馈探头
l 提供电容、电阻、及全细胞补偿机制
l 四极贝塞尔低通滤波器
l 可自发测试信号
l 内置液晶屏显示关键数据
l 前面板操作记录可报表输出
l 三年质保
引用案例：
l Smith AJ, Sugita S, and Charlton MP. (2010) Cholesterol-dependent kinase activity regulates transmitter release from cerebellar synapses. J Neuroscience 30(17): 6116-6121
l Del Negro CA et al. (2009) Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro. J Physiology 587: 1217-1231
l Olsen SR and Wilson RI. (2008) Lateral presynaptic inhibition mediates gain control in an olfactory circuit. Nature 452:956-960
l Yao CA, Ingell R, and Carlson JR (2005) Chemosensory coding by neurons in the coeloconic sensilla of the Drosophila Antenna. J Neuroscience 25(37): 8359-8367
细胞内放大器
Model 3100 细胞内放大器
产品特点：
l 方波发生器可测试电极电阻和电容补偿
l 单个电极可同时刺激和记录
l 低通和陷波滤波器
l 电极阻抗可测量
主要参数：
l Noise (10Hz - 50kHz): 18 μV, rms shorted; < 350 μV with 20 Megohm source
l Input impedance: 10^13 ohms; capacitance adjustable to zero
l Bias current: Adjustable to zero
l Voltage gain: x1 and x10
l Capacity Compensation: -4 pF - 35 pF
l DC Offset: ±1 V
l Max internal current: 1 μA
l External current: 100 nA/V; 10 V maximum
l Electrode test: 100 Hz, 10 nA; (i.e. 10 mV/Megohm electrode resistance)
l Ringer: 0 - 10 V biphasic, 2 - 8 kHz
引用案例：
l Suadicani SO et al. (2009) Point mutation in the mouse P2X7 receptor affects intercellular calcium waves in astrocytes. ASN Neuro 1(1):55-63
l Lowe GC, Luheshi GN, and Williams S (2008) Maternal infection and fever during late gestation are associated with altered synaptic transmission in the hippocampus of juvenile offspring rats. Am J Physiol Regul Integr Comp Physiol 295: R1563-R1571

细胞外放大器
Model 1700四通道差分AC放大器
Model 1800双通道微电极AC放大器
Model 1700/1800应用于可兴奋组织（神经和肌肉等）细胞外神经电生理记录，可记录EMG/EEG/EKG/ERG，供教学和科研使用。Model 1800需连接转换头使用。
每通道放大器包含高增益低噪声的差分电极并跟随有低通、高通、陷波滤波器。每路还包含刺激电极，可在同一电极上发生刺激和记录。
主要参数：
l Gain* x100, x1000, x10000
l High Pass Filter* 0.1, 1.0, 10, 100, and 300 Hz; -40 dB / decade
l Low Pass Filter* 500, 1000, 5000, 10000, and 20000 Hz; -40 dB / decade
l Notch Filter >-35dB at 50 or 60 Hz.(Model 1700)
l Notch Filter >-25dB at 50 or -30dB at 60 Hz.(Model 1800)
l Noise 1.0 microvolt p-p typical (10 Hz to 10,000 Hz)
l Common Mode Rejection > 80 dB
注：标*的参数可根据需要收费定制
引用案例：
l Chen FP and Evinger C (2006) Cerebellar modulation of trigeminal reflex blinks: Interpositus neurons. J Neuroscience 26(41):10569-10576
l Weiss SA, Preuss T, and Faber DS (2009) Phase encoding in the Mauthner system: Implications in left-right sound source discrimination. J euroscience 29(11)3431-3441
l Werk CM and Chapman CA (2003) Long-term potentiation of polysynaptic responses in layer V of the Sensorimotor Cortex induced by Theta-patterned tetanization in the awake rat. Cerebral Cortex 13(5): 500-507

细胞外放大器
Model 3500 16通道差分AC放大器
Model 3500/3600应用于可兴奋组织（神经和肌肉等）细胞外神经电生理记录，可记录EMG/EEG/EKG/ERG，供教学和科研使用。Model 3600需连接转换头使用。该产品在传统产品的基础上，不仅提供更强大的参数配置功能，并且实验参数还可通过触屏或windows软件控制。日志功能可提供实验数据的时间戳方便数据的整理。
主要参数：
l Gain*: 10, 20, 50, 100, 200, 500, 1000, 2000, 5000,10000, 20000
l High Pass Filter* 0.3, 1.0, 3.0, 10, 30, 100, 300, and 500 Hz; -40 dB / decade
l Low Pass Filter* 0.1, 0.3, 0.5, 1.0, 3.0, 5.0, 10.0, and 20.0 kHz; -40 dB / decade
l Notch Filter >-35 dB at 50 or 60 Hz.
l Noise: 2.0 microvolt rms typical (10 Hz to 10,000 Hz)
注： 标*的参数可根据需要收费定制
引用案例：
l Lu H, et al. (2007) Synchronized delta oscillations correlate with the resting-state functional MRI signal. PNAS 104 (46): 18265-18269
l Viggiano A., et al. (2010) Mastication overload causes an increase in O2- production into the subnucleus oralis of the spinal trigeminal nucleus Neuroscience 166(2):416-421
Model 3800 八路可编程刺激发生器
Model 3800 八路可编程刺激发生器应用非常广泛。它高度灵活，可同时发生8路单相或两相脉冲序列，此外，使用内置协议，可非常容易地发生步进脉冲或成对脉冲。
主要参数：
l Timing Rage: 1 μs to 250 Hours
l Minimum Pulse Duration: 1 μs monophasic; 2μs biphasic
l Minimum Pulse Interval: 1 μs monophasic; 2μs biphasic
l Timing Accuracy: Better than 0.02%
l Output: ± 10 V; ± 20 mA, with 1mV resolution
l With Optional SIU: ± 100 V; ±10 mA, with selectable AC coupling; 500kHz bandwidth
l Built-in Stimulus Protocols: Monophasic, Biphasic, Paired Pulse, and Stepped pulse
l Triggering: 8 Channel-specific rear panel BNCs; 3 non-specific front panel BNCs that can be assigned to any single or set of channels; Interchannel triggering
l Gating: 3 non-specific front panel BNCs that can be assigned to any single or set of channels; Interchannel gating

刺激发生器
Model 4100 单通道高能可编程刺激发生器
Model 4100 是A-M Systems公司推出的功能最强大、使用最灵活的可编程刺激发生器，在各种场景得到广泛应用。发生器可发生多种波形，并且用户和通过自定义发生需要的波形。
典型应用：
l long-term potentiation (LTP)
l nerve conduction
l long-term depression (LTD)
l evoked potentials
l classical conditioning
l lesions
l field stimulation
l kindling / seizure models
主要参数：
l Amplitude: -200 V to 200 V @ 100 mA
l Minimum Event Width: 1 microsecond
l Maximum Event Width: 25 hours
l Minimum Event Interval: 2 microseconds
l Bandwidth: 1MHz
l Trigger Options: Manual, External, or Free-Run
l Software: Windows, OSx, Matlab, LabView, iOS, Android