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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 形态:
液体
- 克隆性:
多克隆
- 宿主:
兔
- 浓度:
1mg/1ml
- 抗体英文名:
CD19
- 规格:
50ul
Concentration: 1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background: CD19 is a transmembrane glycoprotein that is delectively expressed on the cell surface of B-lymphocytes,where it activates intracellular signaling cascades involving both Ras and phosphatidylinositol 3-kinase pathways.Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Also known as: Antibody deficiency due to defect in CD19, included; AW495831; B lymphocyte antigen CD19; B lymphocyte surface antigen B4; B4; CD 19; CD19 antigen; CD19 molecule; Cd19 protein; Differentiation Antigen CD19; Leu 12; Leu12; Lymphocyte Surface Antigen; MGC109570; MGC12802; T-cell surface antigen Leu-12.
Specificity: 1 Rabbit Polyclonal IgG, affinity purified by Protein A.
2 Reacts with: Human, Mouse, Rat, Pig, Guinea Pig, .
3 Immunogen: KLH conjugated synthetic peptide derived from human CD19 (171-220aa).
4 Predicted Molecular Weight: 59kDa.Storage: Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles). Application: WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:100-500 Flow-Cyt=1μg /Test ICC=1:100-500 IF=1:50-200
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文献和实验CD19 分子 CD19 常用单克隆抗体或代号: B4,Leu12 主要表达细胞: B,Pre,FDC [B] 分子质量(kDa)和结构: gp90(IgSF) 功 能: 与CD21、CD81组成复合物,调节B细胞活化 CD19 Response regulator that plays a dominant role in establishing signaling
CD19 / CD81 白细胞分化抗原及其功能 CDl9 CDl9分子胞膜外区结构属IgSF,包括2个C2样区,胞质区较长,不同种属间有很高的同源性,含有可发生磷酸化的丝/苏氨酸和酪氨酸残基。CDl9分子分布于除浆细胞外的B细胞谱系发育的各个阶段,也是与B细胞识别、黏附和活化有关的CD分子的结构B细胞的重要标记。 此外CDl9还表达于生发中心的FDC,以及某些急性髓细胞白血病细胞。CDl9是CDl9/CD21/CD81信号复合
抗体的结构决定了其对应的功能,同一抗体的V区和C区的氨基酸组成和顺序不同,决定了其功能上的差异。V区和C区的组成和结构,决定了抗体的生物学功能。 图1:抗体的主要功能(图片来源:Abbas et al: Cellular and Molecular Immunology, 7e.) 1、特异性识别功能 抗体可以通过其结构上的可变区域与抗原结合,同时,具有极高的特异性。这种特异性识别功能可以使抗体识别和结合到感染的病原体,肿瘤细胞等不同种类的分子,帮助免疫系统识别并定位到这些分子,进而启动
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