Bekanamycin (Kanamycin B) 是一种氨

Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain^[1][2].

Bekanamycin (Kanamycin B) is a precursor for semisynthetic antibiotics such as Arbekacin and Dibekacin and is generally extracted from the broth of S. kanamyceticus^[2].
Bekanamycin (Kanamycin B) in a concentration-dependent fashion reduces reversibly the quantal content of the end-plate potentials while it has no observable effect on the configuration of the extracellularly recorded presynaptic action potential. The reduction in evoked transmitter release produced by Bekanamycin could be antagonized either by increasing the external calcium concentration or by drugs like the aminopyridines which are to greatly enhance transmitter release from motor nerve terminals. Bekanamycin exerts potent inhibitory effects on transmitter release probably by interfering with the influx of calcium that occurs during depolarization of motor nerve terminals^[3].

483.51

Solid

C₁₈H₃₇N₅O₁₀

4696-76-8

卡那霉素B杂质3

• Antibiotics
• Disease Research
• Antibacterial

• Antibiotics
• Other Antibiotics

Streptomyces kanamyceticus

Room temperature in continental US; may vary elsewhere.

H₂O : ≥ 100 mg/mL (206.82 mM)

DMSO : 1 mg/mL (2.07 mM; ultrasonic and warming and heat to 80°C)

* "≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 25 mg/mL (51.71 mM); Clear solution; Need ultrasonic

• [1]. Gao W, et al. Modulation of kanamycin B and kanamycin A biosynthesis in Streptomyces kanamyceticus viametabolic engineering. PLoS One. 2017 Jul 28;12(7):e0181971.  [Content Brief]

  [2]. Fosso MY, et al. Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles. J Med Chem. 2015 Dec 10;58(23):9124-32.  [Content Brief]

  [3]. Uchiyama T, et al. Presynaptic effects of bekanamycin at the frog neuromuscular junction. Reversibility by calcium and aminopyridines. Eur J Pharmacol. 1981 Jul 10;72(4):271-80.  [Content Brief]