Apoptosis Activator 2是细胞凋亡有效激活

Therapeutic Potential of siRNA-mediated Targeting of Urokinase Plasminogen Activator, Its Receptor, and Matrix Metalloproteinases

Targeting proteases and their activators would retard the invasive ability of cancer cells, and has been shown to induce apoptosis in certain instances. Various methods have been developed to specifically target protease molecules

细胞凋亡如何检测？

细胞凋亡的过程中起着非常重要的作用，其中caspase-3为关键的执行分子，它在凋亡信号传导的许多途径中发挥功能。Caspase-3正常以酶原(32KD)的形式存在于胞浆中，在凋亡的早期阶段，它被激活，活化的Caspase-3由两个大亚基(17KD)和两个小亚基(12KD)组成，裂解相应的胞浆胞核底物，最终导致细胞凋亡。但在细胞凋亡的晚期和死亡细胞，caspase-3的活性明显下降。 1. Western blot 分析Procaspase-3的活化，以及活化的Caspase-3

Ultraviolet-Induced Apoptosis in Embryonic Stem Cells In Vitro

in these cells are known to include p38 and c-Jun N-terminal protein kinase mitogen-activated protein kinase pathways and activation of a variety of transcription factors, including p53, nuclear factor-�B, and activator protein-1, the nature of the specific