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文献和实验Heterologous Expression Systems and Screening Technologies in Ion Channel Drug Discovery
Drugs acting at the cardiac ion channel level, such as antiarrhythmics, have been in clinical use for several decades, well before the understanding that cardiac excitability was indeed a delicate equilibrium among the activity of specific ion
of biological processes as diverse as insulin release from beta cells in the pancreas through to cardiac and smooth muscle contraction. We have used total internal reflection fluorescence (TIRF) microscopy to watch ion channels
interval on the 12-lead surface electrocardiogram. To date, more than 300 mutations have been identified in five genes encoding key ion channel subunits involved in the orchestration of the heart’s action potential. LQTS genetic testing has been performed
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