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详细说明
新药研发过程中，药物的致心律失常毒性越来越受到关注。FDA即将推出的新指导原则全面致心律失常的心脏安全性评价（CiPA）又会给心脏安全性评价带来怎样的变革。爱思普普已准备好CiPA相关的所有离子通道。
| Channel |
KV11.1,hERG,IKr |
| Catalog Ref. |
ICE-HEK-hERG |
| Gene |
KCNH2 |
| Sources |
human |
| Expression system |
HEK293 |
| Method |
whole cell patch clamp |
| Reference Inhibitor |
E4031, cisapride |
| Target |
QT-prolongation, Torsade de Pointe(TdP) |
2. Nav1.5离子通道
| Channel |
NaV1.5 |
| Gene |
SCN5A |
| Catalog Ref. |
ICE-HEK-Nav1.5 |
| Sources |
human |
| Expression system |
HEK293 |
| Method |
whole cell patch clamp |
| Reference inhibitor |
TTX (1.0μM± 438.7nM) |
| Target |
Brugada syndrome, long QT syndrome, progressive cardiac conduction disease ,dilated cardiomyopathy, sick sinus syndrome, and atrial fibrillation |
3. Cav1.2 离子通道
| Channel |
Cav1.2/β2/α2/δ1, L-type |
| Catalog Ref. |
ICE-CHO-Cav1.2 |
| Gene |
CACNA1C |
| Sources |
human |
| Expression system |
CHO |
| Method |
whole cell patch clamp |
| Reference Inhibitor |
Nifedipine(31.3nM±6.8nM), verapamil |
| Target |
Timothy syndrome, long QT syndrome, Pain, epilepsy, hypertension, stroke, arrhythmia, Autism |
4. Iks离子通道
| Channel |
KvLQT/minK, IKs |
| Gene |
KCNQ1/KCNE1 |
| Sources |
Human |
| Catalog Reference |
ICE-HEK-IKs |
| Expression system |
HEK293 |
| Method |
whole cell patch clamp |
| Standard time |
2 weeks |
| Reference compound |
Chromanol 293B (1.5µM±0.171µM) |
| Target |
Atrial fibrillation |
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