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- 2026年01月28日
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离子通道靶点筛选
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北京爱思益普
TRP (transient receptor potential) 通道是一类在外周和中枢神经系统分布很广泛的通道蛋白.到目前为止,有超过30个TRP通道家族成员在哺乳动物中被克隆。
TRP离子通道与多种感官反应包括热、冷、疼痛、压力、嗅觉和味觉等密切相关，容易被天然芳香物质调控，是很多疾病的治疗靶点。
TRP离子通道家族
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文献和实验In the past few years the presence of one or another member of the TRP channel family has been described basically in all tissues studied. Moreover, the pattern of expression and the susceptibility to modulators of each channel subtype
Methods to Study the Effects of TRP Channel Drugs on Vascular Endothelial Cell Function
of the TRP channel interaction [co-immunoprecipitation, double immunofluorescence staining, chemical cross-linking, and F�rster resonance energy transfer (FRET) detection]; (3) detection of TRP channel-mediated intracellular Ca2+ changes using fluorescence
Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells
-2 in isolated wild-type (WT) and gene-deficient mouse PASMC. We also describe here the manganese-quenching method to determine the role of nonselective cation influx through transient receptor potential (TRP) channels in response to hypoxia.
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