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- 文献和实验
- 技术资料
- 服务名称：
PCR芯片
- 提供商：
SABio
先兆子痫PCR基因芯片可以同时检测影响胎盘发育失调的84个关键基因的表达。先兆子痫，是一种危及生命的疾病，主要表现为怀孕期间的高血压，胎盘的分娩是现有的唯一的治疗方法。这种疾病发生在孕期小于32周被称为早期，超过32周则被称为迟发性。先兆子痫的原因现在不完全清楚。许多患者会出现胎盘植入的失败，这一现象提示我们虽然病征出现很晚，但可能在更早期先兆子痫就有了影响。一个潜在的分子机制涉及到滋养细胞早期胎盘发育的血管重塑缺陷。随着病情的发展，胎盘缺氧，引起炎症和氧化应激。这些过程导致的免疫细胞（如Th1细胞，中性粒细胞和自然杀伤细胞）的浸润。类似的过程会导致胎儿宫内发育迟缓，或胎儿的生长发育不足。先兆子痫主要的研究方向集中在明确妇女在怀孕期间是否产生先兆子痫的高风险。此外，研究还涉及明确先兆子痫的关键基因及新的治疗靶点，抑制或逆转的条件。利用实时定量PCR，研究者可以方便并且可信地对先兆子痫相关基因进行同时检测。
Placental Genes Dysregulated During Pre-eclampsia: Early-Onset: ABCG2 (BCRP), ANGPT2, ATP1B1, BCL6, BHLHE40, CFD, COL14A1, CRH, DCN, DUSP1, F5, FABP4, FLT1 (VEGFR1), FSTL3, HGF, HSD17B1, HTRA1, IGF1, INHA, INHBA, LEP, LPL, MMP12, SOD1, SPP1, VCAN. Late-Onset: ABCC1 (MRP1), ABCG2, APLN, ATP2A2, BCL6, BHLHE40, C3, CAV1, CD40LG (TNFSF5), CDH13, CLU, CP, CRH, CRHBP, CXCL9, CYP26A1, DUSP1 (PTPN16), F5, FLT1, FSTL3, HBEGF (DTR), HP, HSD17B1, HSP90AA1, HTR3A, HTRA1, IFNG, IGFBP3, IL11, IL15, IL1A, INHA, INHBA, ITGB3, KIT (CD117), KRT19, LEP, MAS1, NCAM1, NDRG1, NTRK2, PDGFD, PGR, QPCT, SERPINA3, SOD1, SPP1, STAT1, TAC1, TGFB1, TREM1. Genes Involved in Pregnancy: Pregnancy Maintenance: ADM, ANGPT2, CRH, CRHBP, DCN, FLT1 (VEGFR1), HIF1A, HLA-G, IL11, KRT19, LEP, PGF, PGR, SOD1, TAC3, TGFB1. Angiogenesis: ANGPT2, C3, CCL2 (MCP-1), CDH13, CXCL10 (INP10), DCN, ENG (EVI-1), FLT1 (VEGFR1), FLT4 (VEGFR2), HIF1A, IL18, IL1A, IL6, IL8, ITGB3, MMP9, NDRG1, NOS3 (eNOS), PGF, TEK (TIE2), VEGFA. Vasodilation: ADM, AGTR1, APLN, MAS1, NOS3 (eNOS). Tissue Remodeling: MMP9, MMP12, PAPPA2, SERPINA3. Inflammation: AGTR1, BCL6, C3, CCL2 (MCP-1), CD40LG (TNFSF5), CRH, CXCL10 (INP10), CXCL9 (MIG), FABP4, IL10, IL15, IL18, IL1A, IL2, IL6, IL8, SERPINA3, SPP1, TAC1, TGFB1, TNF. Oxidative Stress: CLU, CYP26A1, DUSP1 (PTPN16), HIF1A, MMP9, SOD1. Adhesion: CAV1, CD40LG (TNFSF5), CDH13, COL14A1, ENG (EVI-1), FSTL3, ITGB3, NCAM1, SPP1, VCAN. Cells Involved in Pre-eclampsia: Th1 Cells: CD40LG (TNFSF5), IFNG, IL18, IL2, STAT1, TNF, VEGFA. Endothelial Cells: ANGPT2, CAV1, CCL2 (MCP-1), CD40LG (TNFSF5), CDH13, EDN1, FLT4 (VEGFR2), HIF1A, ITGB3, NOS3 (eNOS), TEK (TIE2), TGFB1, VEGFA. Neutrophils: CCL2 (MCP-1), EDN1, IFNG, IL6, IL8, TREM1. Natural Killer Cells: IL2, IL15, IL18. Hemostasis & Heme Metabolism: ABCG2 (BCRP), ATP1B1, ATP2A2, C3, CFD, CYP26A1, F5, HP, INHA, INHBA. Hormones & Growth Factors: ADM, APLN, CRH, CRHBP, EDN1, HBEGF (DTR), HGF, IGF1, INHA, INHBA, LEP, PDGFD, PGF, QPCT, TAC1, TAC3. Signal Transduction: Nitric Oxide Signaling: CAV1, EDN1, ENG (EVI-1), HSP90AA1, NOS3 (eNOS). Insulin Signaling: HTRA1, IGF1, IGFBP3.
| Product | Species | Technology | Cat. No. |
| Pre-Eclampsia PCR Array | Human | Gene Expression | PAHS-163Z |
| Pre-Eclampsia PCR Array | Mouse | Gene Expression | PAMM-163Z |
| Pre-Eclampsia PCR Array | Rat | Gene Expression | PARN-163Z |
Placental Genes Dysregulated During Pre-eclampsia: Early-Onset: ABCG2 (BCRP), ANGPT2, ATP1B1, BCL6, BHLHE40, CFD, COL14A1, CRH, DCN, DUSP1, F5, FABP4, FLT1 (VEGFR1), FSTL3, HGF, HSD17B1, HTRA1, IGF1, INHA, INHBA, LEP, LPL, MMP12, SOD1, SPP1, VCAN. Late-Onset: ABCC1 (MRP1), ABCG2, APLN, ATP2A2, BCL6, BHLHE40, C3, CAV1, CD40LG (TNFSF5), CDH13, CLU, CP, CRH, CRHBP, CXCL9, CYP26A1, DUSP1 (PTPN16), F5, FLT1, FSTL3, HBEGF (DTR), HP, HSD17B1, HSP90AA1, HTR3A, HTRA1, IFNG, IGFBP3, IL11, IL15, IL1A, INHA, INHBA, ITGB3, KIT (CD117), KRT19, LEP, MAS1, NCAM1, NDRG1, NTRK2, PDGFD, PGR, QPCT, SERPINA3, SOD1, SPP1, STAT1, TAC1, TGFB1, TREM1. Genes Involved in Pregnancy: Pregnancy Maintenance: ADM, ANGPT2, CRH, CRHBP, DCN, FLT1 (VEGFR1), HIF1A, HLA-G, IL11, KRT19, LEP, PGF, PGR, SOD1, TAC3, TGFB1. Angiogenesis: ANGPT2, C3, CCL2 (MCP-1), CDH13, CXCL10 (INP10), DCN, ENG (EVI-1), FLT1 (VEGFR1), FLT4 (VEGFR2), HIF1A, IL18, IL1A, IL6, IL8, ITGB3, MMP9, NDRG1, NOS3 (eNOS), PGF, TEK (TIE2), VEGFA. Vasodilation: ADM, AGTR1, APLN, MAS1, NOS3 (eNOS). Tissue Remodeling: MMP9, MMP12, PAPPA2, SERPINA3. Inflammation: AGTR1, BCL6, C3, CCL2 (MCP-1), CD40LG (TNFSF5), CRH, CXCL10 (INP10), CXCL9 (MIG), FABP4, IL10, IL15, IL18, IL1A, IL2, IL6, IL8, SERPINA3, SPP1, TAC1, TGFB1, TNF. Oxidative Stress: CLU, CYP26A1, DUSP1 (PTPN16), HIF1A, MMP9, SOD1. Adhesion: CAV1, CD40LG (TNFSF5), CDH13, COL14A1, ENG (EVI-1), FSTL3, ITGB3, NCAM1, SPP1, VCAN. Cells Involved in Pre-eclampsia: Th1 Cells: CD40LG (TNFSF5), IFNG, IL18, IL2, STAT1, TNF, VEGFA. Endothelial Cells: ANGPT2, CAV1, CCL2 (MCP-1), CD40LG (TNFSF5), CDH13, EDN1, FLT4 (VEGFR2), HIF1A, ITGB3, NOS3 (eNOS), TEK (TIE2), TGFB1, VEGFA. Neutrophils: CCL2 (MCP-1), EDN1, IFNG, IL6, IL8, TREM1. Natural Killer Cells: IL2, IL15, IL18. Hemostasis & Heme Metabolism: ABCG2 (BCRP), ATP1B1, ATP2A2, C3, CFD, CYP26A1, F5, HP, INHA, INHBA. Hormones & Growth Factors: ADM, APLN, CRH, CRHBP, EDN1, HBEGF (DTR), HGF, IGF1, INHA, INHBA, LEP, PDGFD, PGF, QPCT, TAC1, TAC3. Signal Transduction: Nitric Oxide Signaling: CAV1, EDN1, ENG (EVI-1), HSP90AA1, NOS3 (eNOS). Insulin Signaling: HTRA1, IGF1, IGFBP3.
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文献和实验相关实验
基因芯片技术具有快速多样、微型化和自动化等特点在生物医学领域广泛的应用。但由于其基本原理是基于核酸杂交技术，有着内在的缺陷，实验的敏感性和重复性都存在一定问题。核酸杂交较适合于检测基因的表达，不易检测基因组DNA的基因的重排，突变和缺失。而大多数肿瘤性疾病和一些遗传变异和表型的改变与后者有关。为了解决上述问题，我们将芯片技术与荧光PCR技术相结合，设立设计一种含有大量微反应池的PCR基因芯片，以期能快速、准确的对基因的重排，突变和缺失等基因变异进行检测。常规PCR反应产物的检测是电泳后观察获得
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先兆子痫PCR基因芯片Pre-Eclampsia PCR Array
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