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- Leukemia & Lymphoma DNA Methylation PCR Array
- 上海
- 2026年02月12日
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- 文献和实验
- 技术资料
- 服务名称：
Leukemia & Lymphoma DNA Methylation PCR Array
- 提供商：
SAB
| Human Leukemia & Lymphoma DNA Methylation PCR Array, Signature Panel: EAHS-071Z
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| The Human Leukemia & Lymphoma EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 tumor suppressor gene promoters whose hypermethylation has been reported in the literature to occur frequently in a variety of leukemia and lymphomas. Profiling cellular or fresh tissue genomic DNA samples with these arrays may help correlate CpG island methylation status with biological phenotypes. The results may also provide insights into the molecular mechanisms and biological pathways behind oncogenesis and cancer pathology. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the promoter methylation status of 22 different leukemia and lymphoma genes with this DNA methylation PCR array. Both 96-well and 384-well ( 4 X 96 ) formats are available. The EpiTect Methyl II PCR Arrays use the MethylScreen™ Technology provided under license from Orion Genomics, LLC. |
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Cell Cycle: JUNB, MEN1, NPM1, TP53.
DNA Damage & Repair: FANCC, FANCL, NPM1, TP53.
Extracellular Matrix & Adhesion: CD9, CTNNA1, SPOCK2.
Growth & Proliferation: DRD2, MEN1, NPM1, SLC5A8, TP53.
Signal Transduction: DRD2, EXT1, MEN1, NFATC1, NPM1, PER2, TLE1, TP53.
Transcription Factors & Co-Factors: AFF1, CEBPD, HOXA7, HOXB5, JUNB, MAFB, NFATC1, NPM1, TLE1, TP53.
Other: LMNA.
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文献和实验清楚。除上述复合物外，MBD还与几种与转录抑制有关的蛋白有一定关系，如c-ski,N-CoR。二、DNA甲基化与肿瘤形成（一）、CPG岛的高度甲基化肿瘤细胞呈现两种绝然相反的甲基化模式：即整体基因组甲基化不足和CPG岛超甲基化。这两种甲基化模式在肿瘤形成中均起重要作用。现对CPG岛内甲基化的研究比较透彻，其在肿瘤形成中的作用也更加明确。1、候补基因(candidante gene)的分析1986年首先报道[1]人类肿瘤CPG岛超甲基化，直到1996年[2],基于PCR的甲基化技术的出现，对CPG岛甲基
Clonality - X Chromosome Inactivation Assay
can utilize X chromosome inactivation (methylation) to determine the clonality status of a tumor or premalignant lesion in females. The technique is based on a methylation-sensitive restriction enzyme and analysis of a polymorphic locus on the X chromosome
上的嘌呤，再将样品与氯乙醛共同孵育，这样5mC就转变为带有强荧光的乙烯胞嘧啶，荧光的强度与原5mC的水平成正比。这种方法可以直接测定基因组整体5mC水平。其优点是所用试剂价格低廉且稳定性好，避免了放射性污染，但缺点是费时费力，而且氯乙醛是一种有毒的物质。 2.2 特异性位点的DNA甲基化的检测 2.2.1 甲基化敏感性限制性内切酶（methylation-sensitive restriction Endonuclease，MS-RE）-PCR/Southern法 这种方法利用甲基化敏感性限制性内切
