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Modulation of the peri‐infarct neurogliovascular function by delayed COX‐1 inhibition
EMR Lake, J Mester, LAM Thomason… - Journal of Magnetic …, 2017 - Wiley Online Library
… Hardware failure resulted in the death of one rat during the hypercapnic challenge in MRI 7 days after stroke induction; one rat died during ALZET minipump implantation from intracranial bleeding following catheter misplacement, and one rat was euthanized for excessive …
A molecular tweezer ameliorates motor deficits in mice overexpressing α-synuclein
F Richter, SR Subramaniam, I Magen, P Lee, J Hayes… - …, 2017 - Springer
… In some experiments, CLR01 was administered intracerebroventricularly into the left lateral ventricle to WT and Thy1-aSyn mice using osmotic minipumps (Alzet model 1004; Alzet, Cupertino, CA, USA) for 28 days at 0, 1, or 10 μM (n = 16 per group) …
Use of Microcomputed Tomography to Measure the Relaxin-induced Expansion of Intrapubic Ligaments in Mice
HA Zimmerman, RP Kennan, C Zhang… - Comparative …, 2017 - ingentaconnect.com
… 1020; Hollister, CA). Alzet 2001 minipumps were purchased from Duret Alzet
(Cupertino, CA). Alzet minipumps were prepared on the day of dosing, and unprimed pumps were implanted subcutaneously in the animals. ELISA …
Apelin impairs myogenic response to induce diabetic nephropathy in mice
J Zhang, J Yin, Y Wang, B Li, X Zeng - The FASEB Journal, 2018 - fasebj.org
… The mice were then randomly divided into saline groups (C57+saline and kkAy+saline groups; both n = 12), which were intraperitoneally injected, with the micro-osmotic pump Alzet (model 1004; Durect, Cupertino, CA, USA) with vehicle; apelin treatment groups (C57+apelin …
[HTML] Preserving and restoring bone with continuous insulin infusion therapy in a mouse model of type 1 diabetes
JS Nyman, E Kalaitzoglou, RC Bunn, S Uppuganti… - Bone reports, 2017 - Elsevier
… mg/dl), 13-week, STZ-diabetic mice were treated with saline vehicle (0.0 dose) or insulin (Humulin R Insulin, Eli Lilly and Co., Indianapolis, IN) at 1 of 3 doses (0.0625, 0.125, and 0.25 IU/day; n = 4–5 per group) using an osmotic minipump (Model 2004, ALZET®, Cupertino, CA …
Beneficial effects of liraglutide (GLP1 analog) in the hippocampal inflammation
ARC Barreto-Vianna, MB Aguila… - Metabolic brain …, 2017 - Springer
… A sterile cannula (Alzet Brain Infusion, Kit 3) was implanted into the left lateral brain ventricle, according to stereotaxic coordinates (AP: −0,22 mm; ML: +1 mm; DV: −2,5 mm from Bregma) (Paxinos and Franklin 2001). The cannula …
A critical role for both CD40 and VLA5 in angiotensin II–mediated thrombosis and inflammation
EY Senchenkova, J Russell, SA Vital, A Yildirim… - The FASEB …, 2018 - fasebj.org
… IL, USA), an inhibitor of integrin a5b1, administered in 5-mg/kg, intraperitoneal injections 5 times over 14 d, or sCD40L (PeproTech, Rocky Hill, NJ, USA; 10 ng/mouse) by intravenous injection 30 min before data collection or 0.5 ng/min for 7 d using osmotic Alzet Mini-Pump (0.5 …
Effects of central FGF21 infusion on the hypothalamus–pituitary–thyroid axis and energy metabolism in rats
U Yilmaz, S Tekin, M Demir, Y Cigremis… - The Journal of …, 2018 - Springer
… As previously described, the brain infusion kits (ALZET, USA) were placed in the right lateral ventricle and fixed by dental cement [36]. After surgery, all rats of sham and FGF21 groups were allowed to recover for 7 days. Aseptically …
Assessment of nicotine withdrawal-induced changes in sucrose preference in mice
Y Alkhlaif, D Bagdas, A Jackson, AJ Park… - Pharmacology …, 2017 - Elsevier
… Nicotine was dissolved in sterile physiological saline (0.9% sodium chloride). Nicotine (12 and 24 mg/kg/day) was infused through 14-day subcutaneous osmotic minipumps (model 2002, Alzet, Palo Alto, CA, USA). The doses were expressed as the free base of the drug …
Developmental nicotine exposure alters potassium currents in hypoglossal motoneurons of neonatal rat
M Cholanian, J Wealing, RB Levine… - Journal of …, 2017 - physiology.org
Login to your account. Institutional Login. Sign In / Register. PHYSIOLOGY.ORG Home: Journals: AJP-Cell; AJP-Endo; AJP-GI; AJP-Heart; AJP-Lung; AJP-Regu; AJP-Renal; AJP (1898-1976); J Appl Physiol; J Neurophysiol; Physiol …
[HTML] Cellular and Molecular Properties of Neurons: Developmental nicotine exposure alters potassium currents in hypoglossal motoneurons of neonatal rat
M Cholanian, J Wealing, RB Levine… - Journal of …, 2017 - ncbi.nlm.nih.gov
… Developmental nicotine exposure. DNE was achieved by subcutaneous implantation of Alzet 1007D mini-osmotic pumps (Alzet) into pregnant dams on gestational day 5, as previously described (Huang et al. 2004; Luo et al. 2004, 2007) …
mTORC1 pathway disruption abrogates the effects of the ciliary neurotrophic factor on energy balance and hypothalamic neuroinflammation
C André, C Catania, J Remus-Borel, E Ladeveze… - Brain, behavior, and …, 2018 - Elsevier
… The cannula was connected to an Alzet osmotic minimpump (flow rate of 0.25µl/h for 14d, Alzet model 1002 Alzet Charles River, France) via a 120mm-long vinyl tubing (inner diameter 0.69 mm filled with artificial cerebrospinal fluid (aCSF, Tocris), which allowed delivery of …
Role of C16, angiopoietin‐1 and regeneration gene protein 2 in attenuating inflammation in an experimental rat model of autoimmune encephalomyelitis
KW Tian, F Zhang, H Jiang, B Wang… - Journal of anatomy, 2017 - Wiley Online Library
… Preparation of osmotic pumps and drug delivery. Reg-2 and vehicle (0.9% saline) were delivered continuously via implanted Alzet osmotic minipumps for 2 weeks (pump model 2002; 0.5 μL h −1 ; ALZET Osmotic Pumps, Cupertino, CA, USA) …
[HTML] Evaluation of the effects of RP5063, a novel, multimodal, serotonin receptor modulator, as single-agent therapy and co-administrated with sildenafil, bosentan …
L Bhat, J Hawkinson, M Cantillon, DG Reddy… - European journal of …, 2018 - Elsevier
… Alzet 2 ML4 pumps (ALZET Osmotic Pumps, Cupertino, CA) were used for delivery, dispensing a volume of 2 ml and at a delivery rate of 2.5 µg/h. Animals assigned to this group were anesthetized with a mixture of 2–2.5% isoflurane (United States Pharmacopeia, USP) in 100 …
Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1‐linked amyotrophic lateral sclerosis mice
S Watanabe, O Komine, F Endo… - Journal of …, 2017 - Wiley Online Library
… Intracerebroventricular administration of CysC was performed with an Alzet® osmotic pump (model #1004; Alzet Corp, Palo Page 7. Accepted Article … All rights reserved. Alto, CA) with a brain infusion kit (Alzet). To minimize the animals' suffering and pain, the mice …
[HTML] Early transcriptional alteration of histone deacetylases in a murine model of doxorubicin-induced cardiomyopathy
I Piotrowska, M Isalan, M Mielcarek - PloS one, 2017 - journals.plos.org
… Sigma). Mini osmotic pumps (Alzet pumps Model 2002, Charles River) were loaded with 200 μl of either vehicle (PBS), or doxorubicin at a dose of 15 μg/g of body weight, allowing diffusion at 0.5 μl/hour, for a period of 14 days …
[PDF] Intratumoral delivery of bortezomib: impact on survival in an intracranial glioma tumor model
NIM Ramos, R Price, K Hurth - J Neurosurg, 2017 - researchgate.net
… In this study the Alzet mini-osmotic pump was used to bring the drug directly to the tumor in the brain, circumventing the blood-brain barrier; thus making bortezomib an effective treat- ment for GBM … The Alzet pumps were introduced directly into the tumor bed in the brain …
Involvement of the N/OFQ-NOP system in rat morp*hine antinociceptive tolerance: Are astrocytes the crossroad?
L Micheli, E Lucarini, F Corti, R Ciccocioppo… - European journal of …, 2018 - Elsevier
… The caudal edge of the cut was lifted and about 7.0 cm of 28G polyurethane catheter (0.36 mm outer diameter; 0.18 mm inner diameter; Alzet, USA) was gently inserted into the intrathecal space in the midline, dorsal to the spinal cord until the lumbar enlargement …
Effect of Intracerebroventricular Administration of Apelin-13 on the Hypothalamus–Pituitary–Thyroid Axis and Peripheral Uncoupling Proteins
Y Erden, S Tekin, C Tekin, F Ozyalin, U Yilmaz… - International Journal of …, 2017 - Springer
… Osmotic mini-pumps (Alzet 2ML1, USA) were filled with the ape- lin concentrations (aCFS for the rats in the sham group). The pumps were connected to the brain infusion kits which are designed as infused into the lateral ventricle of the rats (Alzet Brain Infusion Kit-1, USA) …
Neonatal rotenone lesions cause onset of hyperactivity during juvenile and adulthood in the rat
M Ishido, J Suzuki, Y Masuo - Toxicology letters, 2017 - Elsevier
… Briefly, Alzet osmotic minipumps (Alzet Corp., Palo Alto, CA, USA) were filled with rotenone, which was dissolved in equal volumes of DMSO and PEG 300 (Sigma) … Alzet osmotic minipumps were implanted under the skin on the back of each rat …
The effects of intracerebroventricular infusion of irisin on feeding behaviour in rats
S Tekin, Y Erden, F Ozyalin, Y Cigremis, C Colak… - Neuroscience …, 2017 - Elsevier
… performing any other process. On the 8th day, Alzet brain infusion kit (DURECT
Corporation, ALZET Osmotic Pumps, CA, USA) was implanted in the right lateral
ventricles of the rats in these three groups. After the surgical procedure …
Developmental plasticity of GABAergic neurotransmission to brainstem motoneurons
LB Wollman, RB Levine… - The Journal of physiology, 2018 - Wiley Online Library
… Pregnant dams were anaesthetized with a subcutaneous injection of keta*mine (25 mg kg −1 ), xylazine (8.0 mg kg −1 ) and acepromazine (1 mg kg −1 ) and an Alzet 1007D mini‐osmotic pump (Alzet Corp., CA, USA) was implanted subcutaneously on gestational day 5, as …
Central Infusion of IGF-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function following Traumatic Brain Injury
SW Carlson, KE Saatman - Journal of neurotrauma, 2018 - liebertpub.com
… 3.0 mm53) 15 minutes following sham injury or CCI. The cannula (brain infusion kit 3, Alzet, Cupertino, CA) was attached to an osmotic minipump (model 1007D, 0.5 µl/hr, Alzet) for … the cannula was secured to the skull using an instant adhesive (Loct*ite 454, Alzet) and a set …
Development of obesity can be prevented in rats by chronic icv infusions of AngII but less by Ang (1–7)
M Winkler, M Bader, F Schuster, I Stölting… - … -European Journal of …, 2018 - Springer
… blue. After implantation of cannulas, osmotic mini-pumps (Alzet® model 2006,
infusion rate 0.15 μl/h, Durect Corporation, Cupertino) were implanted below the
left shoul- der. Mini-pumps were connected to the icv cannulas …
Improved method for cannula fixation for long-term intracerebral brain infusion
Á Sike, J Wengenroth, J Upīte, T Brüning, I Eiriz… - Journal of neuroscience …, 2017 - Elsevier
… Mouse model. 1. Introduction. For the continuous infusion of experimental solutions into selected brain regions of small laboratory animals, eg mice and rats, osmotic pumps (eg ALZET ® osmotic pumps) are widely used. These …
[HTML] Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats
B Changyaleket, ZZ Chong… - Journal of …, 2017 - jneuroinflammation.biomedcentral …
… Alzet osmotic pump installation … Three hours post-SAH, animals in groups 3 and 4 received intracerebroventricular treatment of either vehicle (aCSF) or heparanase inhibitor (OGT2115) via Alzet osmotic pump installation. Values are mean ± SE …
Cholinergic modification of neurogenesis and gliosis improves the memory of AβPPswe/PSEN1dE9 Alzheimer's disease model mice fed a high-fat diet
T Matsuda, T Hisatsune - Journal of Alzheimer's Disease, 2017 - content.iospress.com
… mice. Therefore, we used rivastigmine as a cholinesterase inhibitor in this study.
An Alzet Osmotic Pump 2006 (Alzet, Durect) was implanted subcutaneously into
HFD-fed AβPP/PS1 Tg mice at 4.5 months of age. Each mouse …
Featured Article: Imatinib mesylate (Gleevec) inhibits Notch and c-Myc signaling: Five-day treatment permanently rescues mammary development
R Callahan, BA Chestnut… - Experimental Biology and …, 2017 - journals.sagepub.com
Wap-Int3 transgenic females expressing the Notch4 intracellular domain (designated Int3) from the whey acidic protein promoter exhibit two phenotypes in the mam...
Post-acute delivery of memantine promotes post-ischemic neurological recovery, peri-infarct tissue remodeling, and contralesional brain plasticity
Y Wang, EH Sanchez-Mendoza… - Journal of Cerebral …, 2017 - journals.sagepub.com
The NMDA antagonist memantine preferentially inhibits extrasynaptic NMDA receptors, which are overactivated upon stroke and thought to disturb neuroplasticity. ...
[HTML] Tempol ameliorates and prevents mechanical hyperalgesia in a rat model of chemotherapy-induced neuropathic pain
HK Kim, SH Hwang, S Abdi - Frontiers in pharmacology, 2017 - frontiersin.org
… 1C), on the 20th day after the first paclitaxel injection, the rats that developed neuropathic pain behavior were randomly assigned to either a treatment group (tempol, six rats) or a control group (vehicle, five rats) before the insertion of a mini-osmotic pump (Alzet model 2001 …
[HTML] Accurate Control of 17β-Estradiol Long-Term Release Increases Reliability and Reproducibility of Preclinical Animal Studies
C Gérard, A Gallez, C Dubois, P Drion… - Journal of mammary …, 2017 - Springer
… The Alzet ® system is based on the osmotic pumping mechanism and consists of an osmotic compartment surrounded by a semi-permeable membrane with a single delivery orifice … The maximum release time is six weeks for small animals (www.alzet.com) …
[HTML] Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma
G Futamura, S Kawabata… - Radiation …, 2017 - ro-journal.biomedcentral.com
… Pairwise comparisons were conducted using Student's t-test. Group differences
resulting in p-values < 0.05 were considered significant. Implantation of the Alzet
osmotic pump for convection-enhanced delivery. For the convection …
Dipg-43. Prolonged Convection-enhanced Delivery In The Pons With Sn-38 Loaded Nanoparticles And Irinotecan
AC Sewing, NG Olaciregui… - Neuro …, 2017 - soc-neuro-onc.conference-services …
… dialysis chamber. Prolonged CED (200 μL in 24 hours using an Alzet Osmotic pump) was performed in naïve rats, and maximum tolerated dose (MTD) was determined by neurological follow-up using Rota-rod testing. Orthotopic …
Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties
T Beiert, V Tiyerili, V Knappe, V Effelsberg… - Biochemical and …, 2017 - Elsevier
… 2.3. Osmotic minipump implantation. Subcutaneous osmotic minipump implantation (Alzet Model 1002; Durect Corporation, Alzet Osmotic Pumps, Cupertino, CA, USA) was performed right after cryoinfarction on the back of the mice …
Gallium Maltolate Disrupts Tumor Iron Metabolism and Retards the Growth of Glioblastoma by Inhibiting Mitochondrial Function and Ribonucleotide Reductase
CR Chitambar, MM Al-Gizawiy, HS Alhajala… - Molecular cancer …, 2018 - AACR
… Company (St. Louis, MO). Alzet mini-pumps were obtained from Durect Corporation (Cupertino CA) … A subcutaneous pocket was dissected free to hold the implanted Alzet minipump reservoir (Durect Corporation, Cupertino CA) and then the skin wound closed with sutures …