- ￥2520 - 16380
- Sino Biological
- 北京
- 10109-H02H
- 2026年01月26日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
在-20℃ to -80℃
- 保质期：
12个月
- 英文名：
Recombinant Human CD155 / PVR / NECL5 Protein (Fc Tag)
- 库存：
99
- 供应商：
北京义翘神州科技股份有限公司
- 规格：
100 µg/1 mg
| 规格： | 100 µg | 产品价格： | ￥2520.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥16380.0 |
蛋白名称：Human CD155 / PVR / NECL5 Protein (Fc Tag)
蛋白构建：A DNA sequence encoding the extracellular domain (Met1-Asn343) of human CD155 (P15151-1) was expressed with the C-terminal fused Fc region of human IgG1.
表达宿主：HEK293 Cells
蛋白纯度：> 95 % as determined by SDS-PAGE
蛋白活性：1. Measured by its binding ability in a functional ELISA. Immobilized human CD226 His (Cat: 10565-H08H) at 2 μg/mL (100 μl/well) can bind human CD155 hFc (Cat: 10109-H02H), The EC50 of bind human CD155 hFc is 100-800 ng/mL. 2. Immobilized TIGIT Protein, Human, Recombinant (ECD, His Tag)(Cat:10917-H08H) at 2 μg/ml (100 μl/well) can bind CD155/PVR Protein, Human, Recombinant (ECD, hFc Tag)(Cat:10109-H02H), the EC50 of CD155/PVR Protein, Human, Recombinant (ECD, hFc Tag) is 25-140 ng/mL.
蛋白内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
预测N端：Trp 21
蛋白分子量：The recombinant human CD155/Fc is a disulfide-linked homodimer. The reduced monomer consists of 561 amino acids and predicts a molecular mass of 61.8 kDa. As a result of glycosylation, the rhCD155/Fc monomer migrates as approximately 95-105 kDa band in SDS-PAGE under reducing conditions.
蛋白NP号：P15151-1
蛋白氨基酸序列：Met1-Asn343
蛋白标签：C-human IgG1-Fc
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验2, Zhang, C; et al. TIGIT Can Exert Immunosuppressive Effects on CD8+ T Cells by the CD155/TIGIT Signaling Pathway for Hepatocellular Carcinoma In Vitro. J. Immunother., Pubmed: 32804915
3, Wang, FF; et al. TIGIT expression levels on CD4+ T cells are correlated with disease severity in patients with psoriasis. Clin. Exp. Dermatol., Pubmed: 29512851
4, Wei, H; et al. CD226 Involves in Immune Synapse. J. Biol. Chem.
5, S Hou; et al. CD226 Protein Is Involved in Immune Synapse Formation and Triggers Natural Killer (NK) Cell Activation via Its First Extracellular Domain. JOURNAL OF BIOLOGICAL CHEMISTRY, Pubmed: 24451371
6, CJ Chan; et al. The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Nature immunology, Pubmed: 24658051
状。Langerhans细胞具有CD1，HLA-DR和S-100蛋白等免疫标记。电镜下可见胞浆内有一特殊的细胞器称为Langerhans小体或Birbeck颗粒。这是一种呈杆状的管状结构，中央有一纵形条纹和横行平行排列的周期性条纹，形似一条小拉链。有时一端有泡状膨大似网球拍状。Birbeck颗粒是Langerhans细胞所特有的超微结构特征。 组织细胞增生症X时，增生组织细胞的表型、细胞化学和功能等都与Langerhans细胞非常相似，因此目前认为组织细胞增生症X是Langerhans细胞或其前身的增生
佚名 组织细胞增生症 X（histiocytosis X）包括Letterer-Siwe病，Hand-Schüller-Christian病和骨的嗜酸性肉芽肿（eosinophilic granuloma）3种疾病。这三种疾病的临床表现和病理变化不同。Letterer-Siwe病为急性弥漫性，发展快，常表现为恶性过程；Hand-Schüller
【参考值】 凝血酶原：83%～127% 因子V：50%～150% 因子VII：65%～135% 因子X：45%～155% 【临床意义】 将病人血浆分别与测定凝血酶原基质血浆（人工制备凝血酶原血浆），测定因子V用的基质血浆（储存血浆或先天性因子V缺乏症患者血浆，凝血酶原时间测定应>1分钟），测定因子VII用的基质血浆（先天性因子VII缺乏症患者的血浆。基质血浆也可采用先天性因子VII缺乏症患者血浆与正常人硫酸钡吸附血浆等量混合），测定因子X
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