手机验证
腺病毒|腺病毒包装服务|腺病毒载体|Adenovirus|ADV
OBiO和元生物
PFU/mL
和元生物践行“赋能基因治疗,共守生命健康”的使命,以核心技术升级、工艺开发升级、成本控制升级,提升基因治疗递送载体的可及性。即日起, AAV包装低至4380元起,慢病毒包装低至2180元起,用实业回报社会、用科技振兴行业,让基因递送触手可及!
腺病毒包装/腺病毒载体/Adenovirus
腺病毒(Adenovirus, ADV)是一种无包膜的线性双链DNA病毒,其空间结构为立体对称的20面体,衣壳由252个壳粒组成,直径在100nm左右。现已知有51种腺病毒,根据组织嗜性不同被分成ABCDEF六个不同亚群,其中C亚群的第2和第5血清型为最常见的腺病毒载体。
ADV特点
ADV体外感染HUVEC DOI: 10.1016/j.cmet.2021.04.006
部分客户文章列表
1. (IF=29.983) Li L, Fu W, Gong X, et al. The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction[J]. European Heart Journal, 2021, 42(14): 1415-1430.
2. (IF=27.287) Ji Y X, Wang Y, Li P L, et al. A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis[J]. Cell Metabolism, 2021, 33(6): 1171-1186. e9.
3. (IF=25.617) Fu Z, Zhang X, Zhou X, et al. In vivo self-assembled small RNAs as a new generation of RNAi therapeutics[J]. Cell research, 2021, 31(6): 631-648.
4. (IF=25.617) Fu G B, Huang W J, Zeng M, et al. Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens[J]. Cell research, 2019, 29(1): 8-22.
5. (IF=12.27) Zou Y, Wang A, Huang L, et al. Illuminating NAD+ metabolism in live cells and in vivo using a genetically encoded fluorescent sensor[J]. Developmental cell, 2020, 53(2): 240-252. e7.
6. (IF=11.981) Jiang H, Jia D, Zhang B, et al. Exercise improves cardiac function and glucose metabolism in mice with experimental myocardial infarction through inhibiting HDAC4 and upregulating GLUT1 expression[J]. Basic Research in Cardiology, 2020, 115(3): 1-16.
7. (IF=10.717) Zhang Y, Xue W, Zhang W, et al. Histone methyltransferase G9a protects against acute liver injury through GSTP1[J]. Cell Death & Differentiation, 2020, 27(4): 1243-1258.
8. (IF=10.122) Ma X, Zhou Z, Chen Y, et al. RBP4 functions as a hepatokine in the regulation of glucose metabolism by the circadian clock in mice[J]. Diabetologia, 2016, 59(2): 354-362.
9. (IF=9.461) Zhang W, Yang D, Yuan Y, et al. Muscular G9a regulates muscle-liver-fat axis by musclin under overnutrition in female mice[J]. Diabetes, 2020, 69(12): 2642-2654.
10. (IF=8.579) Li Y, Chen M, Zhou Y, et al. NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease[J]. Theranostics, 2020, 10(8): 3579.
11. (IF=8.579) Yu W, Sun S, Xu H, et al. TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury[J]. Theranostics, 2020, 10(24): 11244.
12. (IF=8.469) Zheng Z, Li Y, Fan S, et al. WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1[J]. Cell death & disease, 2021, 12(3): 1-16.
13. (IF=8.460) Liu D, Tian X, Liu Y, et al. CREG ameliorates the phenotypic switching of cardiac fibroblasts after myocardial infarction via modulation of CDC42[J]. Cell death & disease, 2021, 12(4): 1-16.
14. (IF=6.832) Zheng D, Zhou H, Wang H, et al. Mesenchymal stem cell-derived microvesicles improve intestinal barrier function by restoring mitochondrial dynamic balance in sepsis rats[J]. Stem Cell Research & Therapy, 2021, 12(1): 1-21.
15. (IF=6.831) Shao C, Yang X, Jing Y, et al. The stemness of hepatocytes is maintained by high levels of lipopolysaccharide via YAP1 activation[J]. Stem cell research & therapy, 2021, 12(1): 1-17.
病毒载体比较
AAV
和元生物生产的每一个rAAV都经历数十道工序的锤炼,随机检测的rAAV空壳率<2%、内毒素<2.5EU/mL;同时,每批rAAV产品在出库前均会进行多轮滴度测定,保证产品的滴度准确,更好地指导实验研究。此外,我们使用大规模GMP级病毒包装质粒,用于研究级rAAV病毒载体的生产,全力减少批次间差异,降低杂质及污染,让基因递送触手可及!
AAV中包 总量1.0E+12 v.g., 滴度≥1.0E+12 v.g./mL |
病毒包装4380元/个;过表达全套7480元/套;干扰定制(单靶点)5480元/个;干扰全套14000元/套 |
AAV大包 总量5.0E+12 v.g., 滴度≥5.0E+12 v.g./mL |
病毒包装6580元/个;过表达全套9680元/套; 干扰定制(单靶点)7680元/个 |
AAV超大包 总量1.0E+13 v.g., 滴度≥1.0E+13 v.g./mL |
病毒包装8780元/个;过表达全套11880元/套; 干扰定制(单靶点)9880元/个 |
AAV现货 光/化学遗传学、钙成像、递质探针、Cre酶 |
25μL现货:800元/支;50μL现货:1280元/支;100μL现货:2280元/支; |
慢病毒中包 1.0E+8TU (基因3kb以内) |
过表达全套4580元/套 基因合成+载体构建+质粒抽提+病毒包装+滴度检测+对照病毒(仅限库存对照) |
干扰定制(单靶点)2180元/个 载体构建+质粒抽提+病毒包装+滴度检测+对照病毒(仅限库存对照) |
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干扰全套6480元/套 | |
载体构建+质粒抽提+病毒包装+滴度检测+对照病毒(仅限库存对照) | |
慢病毒包装2580元/个 质粒抽提+病毒包装+滴度检测 |
让基因递送触手可及!
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