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- 2025年12月05日
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- 文献和实验
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- 保存条件：
4°C, sealed storage, away from moisture and light
- 英文名：
SDX-105
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
3543-75-7
- 规格：
5 mg/10 mg/25 mg/50 mg/100 mg/200 mg/500 mg
| 规格： | 5 mg | 产品价格： | ￥180.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥260.0 |
| 规格： | 25 mg | 产品价格： | ￥417.0 |
| 规格： | 50 mg | 产品价格： | ￥585.0 |
| 规格： | 100 mg | 产品价格： | ￥820.0 |
| 规格： | 200 mg | 产品价格： | ￥1150.0 |
| 规格： | 500 mg | 产品价格： | ￥1845.0 |
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Bendamustine hydrochloride
CAS No. : 3543-75-7
MCE 国际站：Bendamustine hydrochloride
产品活性：Bendamustine hydrochloride (SDX-105)，一种嘌呤类似物，是一种 DNA 交联剂。Bendamustine hydrochloride 可激活 DNA 损伤反应和细胞凋亡 (apoptosis)。Bendamustine hydrochloride 具有有效的烷基化，抗癌和抗代谢作用。
研究领域：Cell Cycle/DNA Damage | Apoptosis
作用靶点：DNA Alkylator/Crosslinker | Apoptosis
In Vitro: Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. Bendamustine uniquely regulates apoptosis pathways and DNA repair pathways in non-Hodgkin's lymphoma cells. Bendamustine (50 μM) induces p21 (Cip1/Waf1) and NOXA genes, and increases the expression of p53 in SU-DHL-1 cells. Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe.
?Bendamustine reduces the viability of multiple myeloma (MM) cell lines, such as RPMI-8226 and 8226-LR5 cells, with IC25s of 101.8 μM and 585.5 μM after 24 h incubation, and 51.7 and 374.3 μM after 48 h incubation, respectively. Bendamustine induces a specific caspase-dependent MM cell death and inhibits the spindle-assembly checkpoint.
In Vivo: Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model.
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Resolution of Quadruplex Polymorphism by Size‐Exclusion Chromatography
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