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PD‑L1 Fc Chimera, Human 

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  • ExCell Bio已认证
  • CB055-2951
  • 2025年12月11日
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      50.0μg 

    Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a protein that in humans is encoded by the CD274 gene. PD-L1 is a 40 kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Normally the immune system reacts to foreign antigens where there is some accumulation in the lymph nodes or spleen which triggers a proliferation of antigen-specific CD8+ T cell. The formation of PD-1 receptor / PD-L1 or B7.1 receptor /PD-L1 ligand complex transmits an inhibitory signal which reduces the proliferation of these CD8+ T cells at the lymph nodes and supplementary to that PD-1 is also able to control the accumulation of foreign antigen specific T cells in the lymph nodes through apoptosis which is further mediated by a lower regulation of the gene Bcl-2. PD-L1 binds to its receptor, PD-1, found on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition.
    Recombinant Human PD-L1(B7-H1) Fc Chimera produced in CHO cells is a polypeptide chain containing 457 amino acids. A fully biologically active molecule, rh PD‑L1(B7-H1) has a molecular mass of 70-72 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at ExCell Bio.

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    • Quantification of Human IgG and Related Fc Fusion Proteins by a Human IgG/Fc Capture ELISA

      of recombinant human IgGs after production and purification for further assays. Here, we describe a human IgG/Fc capture enzyme linked immunosorbent assay (ELISA) which is simple, robust, inexpensive and specific for all types of human IgGs and related Fc fusion

    • Generating NK Cell Receptor-Fc Chimera Proteins from 293T Cells and Considerations of Appropriate Glycosylation

      cells. We present here (i) a detailed protocol for the production and purification of soluble recombinant NK cell receptors tagged with human IgG1-Fc (thus termed receptor-Fc chimera or receptor-Ig fusion protein) and (ii) a protocol for cell staining

    • Fc受体 Fc receptor

         为对兔疫球蛋白Fc部分c末端的受体。对具有该受体的细胞,通过抗体与抗原结合时,细胞将发挥如下的特有机能:(1)原噬菌体对IgG,占多形核白细胞大部分的嗜中性细胞对IgG、IgA具有Fc受体,通常通过与抗原结合的抗体以及有时与游离的抗体(嗜细胞性抗体)结合来捕捉抗原,并经吞噬作用将之围吞。(2)B细胞的大部分(80%以上)具有对IgG的Fc受体,这些都不进行产生抗体的细胞分化,可通过与抗原抗体复合体的结合而被活化,释放产生抗体的细胞限制因子。(3)T细胞约有10%具有Fc受体,主要

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