TGFβ-1, human

Description：
Transforming Growth Factor β-1 (TGF-β1) is a secreted protein which belongs to the TGF-β family. TGF-β1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGF-β1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGF-β1 peptide. TGF-β1 may also form heterodimers with other TGFβ family members. It has been found that TGF-β1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
Recombinant Human TGF-β1 is produced by our mammalian cells expression system in HEK293 cells. The target protein is expressed with sequence (Leu30-Ser390) of Human TGFB1 fused with a polyhistidine tag at the C-terminus.