- ￥580 - 22680
- Sino Biological
- 北京
- 10119-HNCE
- 2026年08月31日
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AJE 润色服务限时 8 折起，权威机构信任 15+ 年Cytoscape 教程来了！快速实现顶刊同款通路网络图五大应用案例：Mustang Q 膜层析应用全解析1 个小工具，一次性搞定流程图、质粒图谱和信号通路图- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20℃ to -80℃
- 保质期：
12个月
- 英文名：
Human IL18 / IL-18 Protein
- 库存：
99
- 供应商：
北京义翘神州科技股份有限公司
- 规格：
5 µg/10 µg/20 µg/100 µg/1 mg
| 规格： | 5 µg | 产品价格： | ￥580.0 |
|---|---|---|---|
| 规格： | 10 µg | 产品价格： | ￥699.0 |
| 规格： | 20 µg | 产品价格： | ￥1580.0 |
| 规格： | 100 µg | 产品价格： | ￥4480.0 |
| 规格： | 1 mg | 产品价格： | ￥22680.0 |
蛋白名称：重组人IL18 / IL-18蛋白
蛋白构建：A DNA sequence encoding the human IL18 (NP_001553.1) (Tyr37-Asp193) was expressed.
表达宿主：E. coli
蛋白纯度：≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. ≥ 95 % as determined by SEC-MALS(Routinely tested).
生物活性：1.Measured by its ability to induce IFN-gamma secretion by KG‑1 human acute myelogenous leukemia cells in the presence of TNF-alpha. The ED50 for this effect is typically 3-36 ng/ml. 2.Loaded Recombinant Human IL-18R beta / IL-18RAP Protein, hFc & AVI Tag (Cat. No. 10176-H41H-B) on ProA Biosensor, can bind Recombinant Human IL-18Rα Protein, His Tag (Cat. No. 11102-H08H) (Premixed with Human IL-18 Protein, Tag Free, Cat. No. 10119-HNCE) with an affinity constant of 7.7nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 3.Recombinant Human IL-18BP Protein, hFc Tag (Cat. No. 10357-H02H) captured on Protein A chip can bind Recombinant Human IL-18 Protein (Cat. No. 10119-HNCE) with an affinity constant of 14.9 pM as determined in an SPR assay (Biacore 8K) (Routinely tested). 4.Recombinant Human IL-18R beta / IL-18RAP Protein, hFc Tag (Cat. No. 10176-H02H) captured on Protein A chip can bind Recombinant Human IL-18 Protein (Cat. No. 10119-HNCE) (Premixed with Recombinant Human IL-18Rα Protein, His Tag, Cat. No. 11102-H08H) with an affinity constant of 12.85 nM as determined in an SPR assay (Biacore T200) (Routinely tested). 5.Recombinant Human IL18BP Protein (Fc Tag) (Cat: 10357-H02H) captured on Protein A chip, can bind Recombinant Human IL18 / IL-18 Protein (Cat: 10119-HNCE) with an affinity constant of 59.650 pM as determined in an SPR assay (Biacore T200) (Routinely tested). 6.Recombinant Human IL18 / IL-18 Protein (Cat: 10119-HNCE) immobilized on CM5 chip, can bind Recombinant Human IL-18Rα Protein (ECD, Fc & AVI Tag), Biotinylated (Cat: 11102-H41H-B) with an affinity constant of 71.320 nM as determined in an SPR assay (Biacore T200) (Routinely tested). 7.Recombinant Human IL18 / IL-18 Protein (Cat: 10119-HNCE) immobilized on CM5 chip, can bind Recombinant Human IL18BPa Protein (His Tag) (Cat: 10357-H08H) with an affinity constant of 0.321 nM as determined in an SPR assay (Biacore 8K) (Routinely tested). 8.Recombinant Cynomolgus IL-18R beta / IL-18RAP Protein (ECD, His Tag) (Cat: 91110-C08H) captured on CM5 chip via Anti-His antibody, can bind Recombinant Human IL18R1 Protein (Fc Tag) (Cat: 11102-H02H) (Premixed with Recombinant Human IL18 / IL-18 Protein (Cat: 10119-HNCE)) with an affinity constant of 8.750 nM as determined in an SPR assay (Biacore 8K) (Routinely tested).
预测N端：Tyr 37
蛋白分子量：The recombinant human IL18 consists 157 amino acids and predicts a molecular mass of 18.2 kDa. The molecular weight of this protein is around 17.6 kDa verified by SEC-MALS(Routinely tested).
蛋白NP号：NP_001553.1
蛋白氨基酸序列：Tyr37-Asp193
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文献和实验维持，用于疾病模型构建与药物测试。 四、翌圣GMP级重组人IL-9蛋白介绍 为满足细胞治疗药物不同开发阶段的需求，翌圣开发了科研级和GMP级重组人IL-9。我们对GMP级IL-9进行了全面的质量控制测试，保证产品的纯度、活性、安全性和一致性的严格标准。 YEASEN的GMP级重组人Human IL-9蛋白，CHO细胞表达，高活性、高纯度、无动物源性污染。 产品优势 高纯度：>95%，避免宿主蛋白（HCP）或DNA残留导致的免疫
, and enhance IgG2a production in B Cell s. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.[3]
「魔高一尺道高一丈」周挺等 Nature 报道分泌型免疫检查点，伪 IL-18 肿瘤免疫治疗异军突起
. Ring 课题组周挺博士以第一作者在 Nature 上在线发表了题为 IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy 的研究成果。该研究发现肿瘤微环境中产生的 IL-18 结合蛋白（IL-18BP）可能充当「分泌型免疫检查点」限制了 IL-18 免疫治疗的效果；作者通过定向进化的方法筛选得到了一种可维持信号转导能力，但不会被 IL-18BP 抑制的 IL-18（decoy-resistant IL-
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