Product Subcategory:Rabbit Polyclonal Antibody
Cat. No:254201
Unit:0.1 mg
Isotype:Rabbit Ig
Accession No:NP_862823
Applications:E, WB, IHC
Species Reactivity:H, M, R
Application Notes:E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:00-1:500
Antigen:KLH-conjugated synthetic peptide encompassing a sequence within human TRESK.
Format:Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Alternate Names:TRESK; KCNK18; Potassium channel subfamily K member 18; TRIK; TRESK2
Storage:Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Description: TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.