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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件:
-20℃
- 保质期:
12个月
- 英文名:
Recombinant Cluster Of Differentiation 19 (CD19)
- 库存:
1000
- 供应商:
上海信裕
| Organism species | Rattus norvegicus (Rat) |
| Product No. | xy873Ra01 |
| Source | Prokaryotic expression |
| Host | E.coli |
| Purity | > 95% |
| UOM | 50ug |
| Predicted Molecular Mass | 59.7kDa |
| Concentration | n/a |
| Applications | SDS-PAGE; WB; ELISA; IP. |
| Endotoxin Level | <1.0EU per 1µg (determined by the LAL method) |
| Formulation | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
RP QNSLLVEVEE GDNVVLSCLR DSSPVSSEKL AWYRGNQSTP FLELSLRSPD LGLHIGPLGI LLVIVNVSDH RGGFYLCQKR PSFKDTWQPA WTVNVEDSGE LFRWNASDLG DLDCDLGNRS SGSHRSTSGS QLYVWATDHP EVWKTKPVCA PREISLNQSL INQDLTVAPG STLWLSCGVP PVPVTKGSIS WTHVHPKTLN VSLLSLSLGG EHPVREMWVW GSLLLLPQAK ASDEGTYYCL QGGLTIKMHV KVIARSAVWL WLLRTGG
Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and 70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at double intensity to make location and size approximation of proteins of interest quick and easy.
CD19分子(CD19)重组蛋白Ready-to-use: No need to heat, dilute or add reducing agents before use.
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文献和实验CD19 分子 CD19 常用单克隆抗体或代号: B4,Leu12 主要表达细胞: B,Pre,FDC [B] 分子质量(kDa)和结构: gp90(IgSF) 功 能: 与CD21、CD81组成复合物,调节B细胞活化 CD19 Response regulator that plays a dominant role in establishing signaling
CD19 / CD81 白细胞分化抗原及其功能 CDl9 CDl9分子胞膜外区结构属IgSF,包括2个C2样区,胞质区较长,不同种属间有很高的同源性,含有可发生磷酸化的丝/苏氨酸和酪氨酸残基。CDl9分子分布于除浆细胞外的B细胞谱系发育的各个阶段,也是与B细胞识别、黏附和活化有关的CD分子的结构B细胞的重要标记。 此外CDl9还表达于生发中心的FDC,以及某些急性髓细胞白血病细胞。CDl9是CDl9/CD21/CD81信号复合
CAR-T 攻克实体瘤又出新招!超声「遥控」细胞靶向治疗癌症
导读T 细胞在人体抗击肿瘤过程中至关重要,而 CAR-T(嵌合抗原受体 T)细胞,即被基因工程改造的 T 细胞,具有针对癌细胞的定向特异性,是一种很有前景的治疗癌症的方法。对白血病和淋巴瘤细胞具有强大的杀伤作用,近年来发展迅猛、方兴未艾。然而,CAR-T 疗法的毒副作用也不容忽视。CAR-T 在识别和杀伤肿瘤细胞时,是通过肿瘤细胞表面的抗原进行识别的,比如 CD19CAR-T 在治疗急性 B 淋巴细胞白血病的过程中,CAR-T 细胞通过识别肿瘤细胞表面的 CD19 抗原而杀伤肿瘤。但是,正常
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