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【简单介绍】
Identity:Histidyl tRNA synthetase, HisRS, histidine translase.Source Material:Bovine thymus (New Zealand origin).Clinical Indications:Autoantibodies present in polymyositis, dermatomyositis.Ordering I【详细说明】
AROTEC_Jo-1_MSDS.pdf
Version/Date: B/04.05.26
MATERIAL SAFETY DATA SHEET
Product: Jo-1 antigen, from bovine thymus
Synonym: Histidyl-tRNA Synthetase / Histidine-tRNA Ligase / HISRS
E.C. No.: 6.1.1.21
CAS Registry No.: not available
Catalog No.: ATJ01-02, ATJ01-05, ATJ01-10
*****************************************************************************************
Page 1 of 3
AroTec Diagnostics Limited, 10 Hutt Road, Petone, P.O. Box 38586 Wellington Mail Centre, Wellington 6332, New Zealand
Tel: +64-4-5690361 ¬ Fax: +64-4-5690366 email: info@arodia.com
Composition Information
Chemical Formula/Composition: N/A
Physical Description: Clear, colourless liquid/frozen liquid
Stability/Reactivity: Stable. Hazardous decomposition or polymerization will not occur.
*****************************************************************************************
Hazard Identification(s)
Hazards identified with this product are those associated with the following component(s):
Glycerol, DNase, RNase and Protease free
CAS Registry No.: 56-81-5
Concentration: 20% v/v
Potential Health Effects:
Eye: May cause mild eye irritation.
Skin: May cause mild skin irritation. Low hazard for usual laboratory handling.
Ingestion: May cause gastrointestinal irritation with nausea and diarrhoea. May cause
headache. Expected to be a low ingestion hazard.
Inhalation: Low hazard for usual laboratory handling. Inhalation of mist of this material
may cause respiratory tract irritation.
Chronic: May cause kidney injury.
Potential hazards identified with this product are those associated with the title component
(Jo-1 antigen) and with following buffer and stabilising components present at concentrations
at which they are not normally considered to be hazardous:
Component CAS Registry No. Concentration
4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid
(HEPES)
7365-45-9 <0.5%
Phenylmethylsulfonylfluoride 329-98-6 <0.002%
Dithiothreitol 3483-12-3 <0.005%
Micr-O-protect 64-17-5
30007-47-7
2612-54-3
0.1% AROTEC_Jo-1_MSDS.pdf
Version/Date: B/04.05.26
MATERIAL SAFETY DATA SHEET
Product: Jo-1 antigen, from bovine thymus
Synonym: Histidyl-tRNA Synthetase / Histidine-tRNA Ligase / HISRS
E.C. No.: 6.1.1.21
CAS Registry No.: not available
Catalog No.: ATJ01-02, ATJ01-05, ATJ01-10
*****************************************************************************************
Page 2 of 3
AroTec Diagnostics Limited, 10 Hutt Road, Petone, P.O. Box 38586 Wellington Mail Centre, Wellington 6332, New Zealand
Tel: +64-4-5690361 ¬ Fax: +64-4-5690366 email: info@arodia.com
Toxicological Information:
Toxicological properties have not been fully investigated. May be harmful by ingestion,
inhalation or skin contact. May cause allergic or autoimmune reactions.
*****************************************************************************************
Storage and Handling
Store according to instructions on product and/or package insert.
Avoid contact with material. Wear protective equipment (protective clothing, chemicalresistant gloves, eye protection, respiratory protection) when handling.
Spill or Release of Material:
Wear protective equipment.
Absorb liquid on dry sand, diatomite, vermiculite or other drying agent and place in closed
container for disposal.
Ventilate area and wash spill site after material absorption is complete.
Waste Disposal:
Incinerate or landfill as complies with state and local laws for biological materials.
*****************************************************************************************
First Aid Procedures
Substance in Contact with Skin:
Remove contaminated clothing and rinse with copious amounts of soap and water for a
considerable amount of time. Seek medical aid if irritation develops or persists.
Substance has been Swallowed:
If victim is conscious rinse mouth several times with water, do not swallow. Call a physician or
take victim to hospital.
Substance in Contact with Eyes:
Rinse with copious amounts of water for a considerable time. Seek medical aid if irritation
develops or persists.
Substance has been Inhaled:
Take victim into the fresh air and allow to rest. Call a physician or take victim to hospital.
Additional Instructions:
Observe proper laboratory instructions when handling this material.
***************************************************************************************** AROTEC_Jo-1_MSDS.pdf
Version/Date: B/04.05.26
MATERIAL SAFETY DATA SHEET
Product: Jo-1 antigen, from bovine thymus
Synonym: Histidyl-tRNA Synthetase / Histidine-tRNA Ligase / HISRS
E.C. No.: 6.1.1.21
CAS Registry No.: not available
Catalog No.: ATJ01-02, ATJ01-05, ATJ01-10
*****************************************************************************************
Page 3 of 3
AroTec Diagnostics Limited, 10 Hutt Road, Petone, P.O. Box 38586 Wellington Mail Centre, Wellington 6332, New Zealand
Tel: +64-4-5690361 ¬ Fax: +64-4-5690366 email: info@arodia.com
Fire Fighting Measures
General Information
Structural fire-fighting gear and self-contained breathing apparatus will provide adequate
protection if this product is in a fire area.
Extinguishing Media
In case of fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Unusual Fire and Explosion Hazards
N/A
*****************************************************************************************
Disclaimer
The information provided in this Material Safety Data Sheet is furnished in good faith and
without warranty of any kind. Personnel handling this material must consider these data only
as supplemental to other information gathered by them and must make independent
determinations of the suitability and completeness of information from all sources to assure
proper use and disposal of the materials and the safety and health of employees and
customers. AroTec Diagnostics Limited assumes no liability or responsibility resulting from the
use of, or reliance on, this information.
*****************************************************************************************
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文献和实验能引起抗原抗体反应及免疫反应的物质之总称。在自然界是分子量约为 1000以上的蛋白质和多糖类及其复合物,脂类及其复合物等。抗体并不是与抗原的所有分子起反应,而仅同部分分子(抗原决定簇)相对应的,在抗原中通常有复数抗原决定簇。低分子的人工抗原决定簇(半抗原),其本身虽不能引起兔疫反应,但将半抗原与蛋白质结合给动物注射时,就发生对半抗原的免疫反应。在此情况下,蛋白质是载体。有时自身蛋白质有成为载体与半抗原结合,引起免疫反应或过敏症的。
类: 根据抗原物质所起的作用,分为完全抗原和半抗原。 完全抗原(complete antigen) 简称抗原。是一类既有免疫原性,又有免疫反应性的物质。如大多数蛋白质、细菌、病毒、细菌外毒素等都是完全抗原。 半抗原(hapten)是只具有免疫反应性,而无免疫原性的物质,故又称不完全抗原。半抗原与蛋白质载体结合后,就获得了免疫原性。又可分为复合半抗原和简单半抗原。复合半抗原不具有免疫原性,只具免疫反应性,如绝大多数多糖(如肺炎球菌的荚膜多糖)和所有的类脂等;简单半抗原既不具免疫
抗原修复方法 Antigen Retrieval Methods
虽然固定对于保持组织形态至关重要,但该过程也可能对免疫组化/免疫细胞化学检测产生负面影响。固定会改变蛋白质的生化性质,导致目标表位被掩盖,从而无法与一抗结合。表位被掩盖的原因可能是表位内氨基酸的交联、表位附近或位点无关肽段的交联、表位构象的改变或抗原静电荷的改变。抗原修复是指任何能够逆转表位掩盖并恢复表位-抗体结合的技术。 抗原修复技术 抗原修复的必要性取决于多种因素,包括但不限于目标抗原、所用抗体、组织类型以及固定方法和时间。由于多克隆抗体能够识别多个表位,因此与单克隆抗体相比,它们无需抗原
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