- 询价
- Cell Signaling Technology
- 2690
- USA
- 2025年10月19日
- W
- Rabbit
- H,M,R
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体英文名：
IKKε Antibody
- 抗原：
synthetic peptide corresponding to a region near the carboxyl terminus of IKKε protein
- 应用范围：
W
- 宿主：
Rabbit
- 供应商：
CST
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 适应物种：
H,M,R
- 库存：
大量
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
40 ul (4 western blots)/100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 40 ul (4 western blots) | 产品价格： | ￥请询价 |
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R | Endogenous | 80 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | IKKε Antibody detects endogenous levels of total IKKε protein. This antibody does not cross-react with other IKKs or with TBK1/NAK. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a region near the carboxyl terminus of IKKε protein. Antibodies are purified by peptide affinity chromatography. Western Blotting
Western blot analysis of recombinant IKKε Kinase #7553 and RAW 264.7 cells, untreated or LPS-treated, using IKKε Antibody. |
| Background | The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins (1-3). Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB (3-7). The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit (8,9). Activation of IKK depends upon phosphorylation of Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes resulting in kinase activation (10-13). Recently, two homologs of IKKα and IKKβ have been described, called IKKε (also known as IKK-i) and TBK1 (also known as T2K or NAK). Activation of either of these kinases results in NF-κB activation. IKKε contains the kinase domain in its amino terminus, which shares 30% identity to that of IKKα or IKKβ. IKKε is expressed mainly in immune cells and may play a special role in the immune response (14-18).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验网络 二、CD3γ、δ和 ε链 CD3ε、γ和δ链的cDNA序列分析表明，它们都属于I型跨膜蛋白，都含有一个约有50氨基酸残基组成的类似免疫球蛋白胞外功能域，编码这些肽链的基因密切连锁，可能起源于同一祖先基因。在复合体中，CD3γ、δ和ε以二种非共价键形式γε和δε异源二聚体存在。 ε链分子量为20-25kDa，从编码ε cDNA推算出多肽
免疫球蛋白 Fc 段受体 Fc ε RI/ Fc ε R Ⅱ FcεRI 由一条。链、一条p链和YY二聚体所组成(op丁2)。FctRI。链属IgSF成员，胞膜外区有2个C2样结构域，跨膜区与CDl6跨膜区同源性很高。p链是CD20／FctRIp家族成员。丁链则与FcTRⅢ丁亚单位完全相同，并与CD3(和7)链结构相似。FctRIT链胞质区含有ITAM。FctRI是IgE高亲和力受体，相互结合的部位是FctRa第1个IgSF结构域与IgE重链第3个恒定区Ce3。FceRI丁链
xueruo 你好，本人要做IKK-NF-κB通路方面的研究，做的是胃上皮细胞，指导导师让我用NBD抑制IKK活性，并要求我订购IKKβ磷酸化抗体做IKK活性试验，我有点困惑，查了不少的文献，IKK都是引起IκB磷酸化激活NF-κB的，而非IKK磷酸化激活的，其中的原理是什么?NBD多肽我在文献上看到有野生型，突变型，好多文献里NBD多肽是找公司合成的，肽链有长有短，打电话问公司订，他们要求我提供序列，我也不知道提供什么？恳请各位大侠给出高见，谢谢
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