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- xy-3745
- 2025年07月13日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 文献和实验
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- Micropthalmia Transcription Factor (MITF) Monoclonal Antibody, Purified (SIGNET)详细信息：
-
Description 
Purified Monoclonal Antibody against Micropthalmia Transcription Factor (MITF)
(Formerly Signet Catalog Nos: 745-01, 745-16 L1 Predilute, 745-26 L2 PrediluteIntended Use ** In Vitro Diagnostic (IVD) ** Clone D5 Form Purified Antibody (in 0.01M PBS + 0.1% NaN3 + 1% BSA) Host Mouse IsoType Micropthalmia Transcription Factor (MITF) Monoclonal Antibody, Purified (SIGNET)IgG1 Specificity Signets monoclonal Micropthalmia Transcription Factor (MITF) D5 clone recognizes a nuclear protein which is expressed in the majority of primary and metastatic epithelioid malignant melanomas. MITF is also expressed in normal melanocytes and benign and dysplastic nevi. MITF regulates the development and survival of melanocytes and retinal pigment epithelium. MITF is also involved in transcription of pigmentation enzyme genes including tyrosinase, TRP1 and TRP2.
Concentrated Format:
SIG-3745-1000 [1 mL]
Prediluted Formats:
SIG-3745-16 [6 mL]
SIG-3745-26 [6 mL]
Both are ready-to-use with either a Biotin-based (USA Ultra Streptavidin Detection, SIG-32250) or Biotin-free (ACUITYAdvanced Polymer Detection, SIG-32902) detection systems.Uses Micropthalmia Transcription Factor (MITF) Monoclonal Antibody, Purified (SIGNET)This antibody is effective in immunohistochemistry (IHC). Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - IHC: ≥1:20 (concentrated format) with Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
- IHC: ≥1:20 with polymer based detection systems such as ACUITYAdvanced Biotin Free Polymer Detection (SIG-32902).
Tissue Sections: Formalin-fixed, paraffin-embedded tissues
Pretreatment: For optimal staining, the sections should be pretreated with an antigen unmasking solution such as Sodium Citrate HIER (SIG-31932).
Incubation: 60 minutes at room temperature
Note: Staining pattern should be nuclear. If cytoplasmic staining is observed, further dilution of antibody is required.
Storage Store between 2-8°C. References Du J, Miller AJ, Widlund HR, Horstmann MA, Ramaswamy S, Fisher DE. MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma. Am J Pathol 163(1):333-43, 2003.
Granter SR, Weilbaecher KN, Quigley C, Fisher DE. Role for micropthalmia transcription factor in the diagnosis of metastatic malignant melanoma. Appl Immunohistochem Mol Morphol 10(1):47-51, 2002.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Micropthalmia Transcription Factor (MITF) Monoclonal Antibody, Purified (SIGNET)
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