- 询价
- R&D
- 美国/中国
- xy-550P
- 2025年07月16日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 文献和实验
- 技术资料
- 形态：
液态/粉状
- 保存条件：
-20℃保存
- 克隆性：
多克隆
- 标记物：
见说明书
- 适应物种：
人，大鼠，小鼠，兔
- 宿主：
Goat，Rabbit，Mouse
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 靶点：
来电咨询
- Aph-1aL/C Terminal (245-265) Polyclonal Antibody, Purified保存于运输说明：
- Store at -20°C
- 详细信息：
-
Description 
Polyclonal Antibody against Aph-1a (Aph-1aL, C-Terminal Region), O2C2 Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Form Affinity Purified Antibody Host Rabbit Species Reactivity Aph-1aL/C Terminal (245-265) Polyclonal Antibody, PurifiedHuman [Ab] 0.3 mg/mL Specificity The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic activity. The gamma secretase complex catalyzes cleavage of a number of integral membrane proteins including Amyloid precursor protein, Notch, Erb4 and E-cadherin. While Aph-1 stabilizes the presenilin holoprotein within the gamma secretase complex, Pen-2 is required for endoproteolysis of presenilin and activation of the gamma secretase. The Aph-1 homologue on human chromosome 1 is termed Aph-1a and on human chromosome 15 is referred to as Aph-1b. The antibody Aph-1aL/C-terminal (O2C2) was raised against the human Aph-1aL/C-terminal region and recognizes the sequence CRRQEDSRVMVYSALRIPPED of human Aph-1aL.
Covance also offers an antibody O2F1 (PRB-551P) which recognizes residues 92-115 of the Aph-1aL/ S Loop.Uses This antibody is effective in immunoblotting and immunofluorescence (IF). Suggested Working Dilution Aph-1aL/C Terminal (245-265) Polyclonal Antibody, PurifiedThe optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:1,000
- IF: 1:200
Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. References Gu Y, Chen F, Sanjo N, Kawarai T, Hasegawa H, Duthie M, Li W, Ruan X, Luthra A, Mount HT, Tandon A, Fraser PE, St George-Hyslop P. Aph-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of the presenilin.nicastrin complexes. J Biol Chem 278:7374-7380, 2003. Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Aph-1aL/C Terminal (245-265) Polyclonal Antibody, Purified
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Xia''Xiang Gao''Zhimin Lu''et al.(2009) FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST.Molecular Cell''35:11–25 3.J Bossuyt''K Helmstadter''X Wu''et al.(2008) u Ca
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