Stemolecule™ (-)-Indolactam V

Stemolecule™ (-)-Indolactam V详细信息：
Product Overview

Stemolecule™ (-)-Indolactam V is an inhibitor of protein kinase C (PKC) isozymes (alpha, beta-I, beta-II, gamma, delta, epsilon, eta, theta)1. PKC isozymes play a crucial role in cellular signal transduction via the second messenger, 1,2-diacyl-sn-glycerol (DG)1. Indolactam was identified in a high-content chemical screen as a small molecule inducer of human embryonic stem cell differentiation to functional insulin-secreting beta cells at the definitive endoderm cell stage thereby increasing the number of Pdx1-expressing pancreatic progenitor cells2.

Stemolecule™ (-)-Indolactam V是蛋白激酶C（PKC）同工酶的抑制剂（alpha, beta-I, beta-II, gamma, delta, epsilon, eta, theta），PKC同工酶在第二信使介导的细胞信号转导中具有重要作用。在内胚层细胞形成的决定性阶段，Indolactam是人胚胎干细胞分化成功能胰岛素beta细胞的小分子诱导剂，因而能增加表达Pdx1基因的胰腺原基细胞数目。
Product Specifications

Size / Quantity 300 μg
Alternate Name Indolactam
CAS Number 90365-57-4
Chemical Formula C17H23N3O2
Structure [image]

Stemolecule™ (-)-Indolactam VFormulation White to off-white solid
Molecular Weight 301.38
Purity ≥ 95%
Solubility Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 100 µl of DMSO to the entire contents of the vial.
Storage Store at 4oC. Protect from light. Following reconstitution, store aliquots at -20C.
Stability Stock solutions stable at -20°C for 6 months.
Quality Control The purity of (-)-Indolactam V was determined by HPLC analysis. The accurate mass of Indolactam was determined by mass spectrometry. Cellular toxicity of Indolactam was tested on mouse embryonic stem cells.
Notice to Purchaser Purchaser represents and warrants that it will use Stemolecule™ (-)-Indolactam V purely for research purposes, not for diagnostic use, not for resale, and not for use in humans or veterinary applications. Stemgent will not be held responsible for patent infringement or other violations that may occur with the use of our products.
Stemolecule™ (-)-Indolactam V
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