Stemolecule™ KAAD-Cyclopamine

Stemolecule™ KAAD-Cyclopamine详细信息：
Product Overview

Stemolecule™ KAAD-Cyclopamine是Hedgehog的抗拮剂，Hedgehog 信号涉及胚胎的发育和癌症的发生。Stemolecule™ KAAD-Cyclopamine用于阻止多种癌细胞的迁移和增殖。

Stemolecule™ KAAD-Cyclopamine is a sonic hedgehog antagonist known to target Smoothened1. Hedgehog signaling is involved in embryogenesis as well as cancer progression2. KAAD-Cyclopamine has been utilized to halt the migration or proliferation of a variety of cancer cells (e.g. esophageal3, gastrointestinal4, hepatic5 and pancreatic6 cancer).

Stemolecule™ KAAD-CyclopamineProduct Specifications

Alternate Names 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine; Cyclopamine-KAAD; Shh Signaling Antagonist II; N-[2-[(3R,7aR)-3,6,10,11b-tetramethyl-3-oxospiro[1,2,4,6,6a,6b,7,8, 11,11a-decahydrobenzo[a]fluorene-9,2-3,3a,5,6,7,7a-hexahydrofuro[3, 2-b]pyridine]-4-yl]ethyl]-6-(3-phenylpropanoylamino)hexanamide
Chemical Formula C44H63N3O4
Structure
Molecular Weight 697.99
Stemolecule™ KAAD-CyclopamineCAS Number 306387-90-6
Purity 95%
Formulation Pale yellow solid
Solubility Soluble in DMSO (100 mM), ethanol (1.4 mM), or methanol (1.4 mM). For a 1 mM concentrated stock solution, reconstitute the compound by adding 143 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage Store at 4°C. Protect from light. Following reconstitution, store aliquots at -20°C.
Stability Stock solutions stable at -20°C for 6 months.
Quality Control The purity of KAAD-Cyclopamine was determined by HPLC analysis. The accurate mass and structure of KAAD-Cyclopamine was determined by mass spectrometry and NMR, respectively. Cellular toxicity of KAAD-Cyclopamine was tested on mouse embryonic stem cells.
Stemolecule™ KAAD-Cyclopamine
xy11740 RD(恶性胚胎横纹肌瘤细胞) RD细胞
xy11741 NFS-60细胞,NFS-60细胞
xy11742 mouse N3 mouse N3细胞
xy11743 Mo-MuLv感染的3T3细胞,Mo-MuLv/3T3细胞
xy11744 LLC小鼠 Lewis 肺癌细胞,Lewis细胞
xy11745 Leuwis肺癌细胞,LLC细胞
xy11746 KM小鼠子宫颈癌瘤株 U27细胞
xy11747 KM小鼠未分化神经胶质瘤瘤株 B22细胞
xy11748 KM小鼠网织细胞肉瘤瘤株 LⅡ细胞
xy11749 KM小鼠脑神经胶质母细胞瘤瘤株 G422细胞
xy11750 K562耐阿霉素细胞株 K562/ADP细胞
xy11751 HPVl6 E6、E7和ras基因共转化的C57BL／C(H-2b)小鼠肺上皮细胞,TC-1细胞
xy11752 HEK293,人胚肾上皮细胞,293A细胞
xy11753 EB病毒转化的绒猴淋巴细胞,B95-8细胞
xy11754 EBV 转化的绒猴白细胞,B95-8细胞
xy11755 EB 病毒转化的B 细胞,CGM1细胞
xy11756 CCL13张氏肝细胞正常 Chang liver细胞
xy11757 C57小鼠黑色素瘤瘤株 ME细胞
xy11758 C3H小鼠骨肉瘤 LM8细胞
xy11759 B淋巴细胞, WEHI 22.1细胞
xy11760 Burkitt's 淋巴瘤细胞,Raji细胞
xy11761 Burkitt's 淋巴瘤细胞,NAMALWA细胞
xy11762 BALB/C小鼠胚成纤维细胞,BALB/3T3细胞
xy11763 BALB/C小鼠肝上皮细胞,BNL1ME A.7R.1细胞
xy11764 BALB/c小鼠ES细胞,B/c-ES细胞
xy11765 Asp2人胚胎肾细胞转化细胞,FC33细胞
xy11766 Ad5DNA转化的胚肾 HEK-293细胞
xy11767 615小鼠网织细胞性白血病瘤株 L615细胞
xy11768 615小鼠乳腺癌瘤株 Ca763细胞
xy11769 615小鼠乳腺癌瘤株 Ca761细胞
xy11770 615小鼠乳腺癌瘤株 Ca759细胞
xy11771 615小鼠乳头状肺腺癌瘤株 P615细胞
xy11772 615小鼠前胃癌瘤株 Fc细胞
xy11773 615小鼠滑膜肉瘤瘤株 ZM755细胞
xy11774 615小鼠肺癌瘤株
xy11775 615小鼠T细胞性白血病瘤株 L7912细胞
xy11776 5-8转基因鼻咽癌细胞系 F2-2细胞
xy11777 293T/17人胚肾细胞,293T/17细胞
xy11778 1肝细胞
xy11779 129小鼠ES细胞,E14细胞
xy11780 129小鼠ES细胞,D3细胞
xy11781 (舌鳞癌细胞,Tca-8113细胞