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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4℃保存
- 保质期：
6个月
- 英文名：
Stemolecule RG108
- 库存：
1
- 供应商：
上海信裕
- Stemolecule RG108保存于运输说明：
- 4°C protected from light. Following reconstitution, store aliquots at -20°C
- 详细信息：
-
Stemolecule™ RG108
Stemolecule™ RG108 is the highest purity preparation available, only from Stemgent. RG108 is a cell-permeable, specific DNA methyltransferase inhibitor. The DNA methylation level markedly fluctuates during early embryonic development. Unlike somatic cells that undergo massive apoptosis on loss of the DNA methyltransferase Dnmt1, tolerance of genomic demethylation is a unique property of ES cells. In mouse, three DNA methyltransferases, Dnmt1, Dnmt3a and Dnmt3b, coordinately regulate global methylation in the genome. Embryos exhibit an early-lethal phenotype upon loss of Dnmt1 or Dnmt3a/b1,2. However, both Dnmt1-/- and Dnmt3a-/-/b-/-ES cells are viable when maintained in the undifferentiated status. As the Dnm1-/- ES cells differentiate massive apoptosis occurs, whereas the Dnm3a-/-/b-/- cells are unable to initiate differentiation upon leukemia inhibitory factor (LIF) withdrawal, remaining viable and retaining markers characteristic of undifferentiated ES cells. These cells could not form teratoma in vivo 3,4.
RG108 is a potent small molecule DNA methyltransferase inhibitor, which provides a great tool to study methlytransferase in vivo and in vitro biological functions 5. It is particularly useful due to its non-covalent binding into the enzyme activation domain, which makes the inhibition reversible. RG108 can be used to examine tolerance of global genomic demethylation of induced pluripotent stem (iPS) cells that is one of the unique properties of ES cells. View Poster
Stemolecule RG108产品参数
Alternate Name 2-(1,3-Dioxo-1,3-dihydro- 2H-isoindol-2-yl)- 3-(1H-indol-3-yl)propionic acid Synonym N-Phthalyl-1-tryptophan Chemical Formula C19H14N2O4 Structure Molecular Weight 334.44 CAS Number 48208-26-0 Stemolecule RG108 PubChem Substance ID 24724594 Purity >99% by HPLC analysis Formulation Yellow solid Solubility Soluble in DMSO (100 mM) or ethanol (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 2990 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%. Storage 4°C protected from light. Following reconstitution, store aliquots at -20°C Stability Stock solutions stable at -20°C for 6 months Quality Control RG108 is tested by performing the following assays: in vivo methylation assay, trapping assay by western blot analysis, proliferation assay, and survival viability assay. References - Li, E., et al., Cell (1992) 69: 915-926.
- Okano, MDW, et al, Cell (1999) 99: 247-257.
- Jackson, M., et al., Mol Cell Biol (2004) 24: 8862-8871.
- Tsumura, A., et al., Genes to Cells (2006)11: 805-814.
- Brueckner, B., et al, Cancer Res. 65, 6305-6311 (2005)
- Stemolecule RG108
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xy-0066xy TGF-Alpha (Ttansforming Growth Factor –Alpha)转移生长因子–α（抗原）
xy-0564xy CaMK2a(calcium/calmodulin-dependent protein kinase II alpha)钙/钙调素依赖蛋白激酶2α抗原
xy-1809xy Camk1g(Calcium/calmodulin dependent protein kinase IG)钙/钙调蛋白依赖蛋白激酶IG抗原
xy-0103xy TGF- Beta1 (Ttansforming Growth Factor – Beta1)转移生长因子–β1（抗原）
xy-0541xy CaMK2b(calcium/calmodulin-dependent protein kinase II beita)钙/钙调素依赖蛋白激酶2b抗原
xy-1306xy CAP1/Park7/DJ-1Park7/DJ-1/CAP1抗原
xy-1616xy CAP2(Adenylyl cyclase-associated protein 2)环化酶相关蛋白CAP-2抗原
xy-0100xy TGF beta 2 Propeptide转移生长因子–β2前体肽
xy-0099xy TGF- Beta3 (Ttansforming Growth Factor – Beta3)转移生长因子–β3（抗原）
xy-0117xy TGF- Beta R2 peptide转移生长因子β受体2（多肽抗原）
xy-0226xy Thymosin Alpha-1胸腺肽 α-1 （胸腺肽-Thymosin alpha-1）
xy-1105xy Caspase-12半胱胺酸蛋白酶蛋白-12(多肽)
xy-0967xy Caspase-12(hunman)半胱胺酸蛋白酶蛋白-12抗原(人)
xy-0054xy TmR2(GDNFR Beta；TRN-R；GFR-alpha-2；NTNR-2)胶质细胞系源性神经营养因子（多肽）
xy-0078xy TNF-Alpha(Tumor Necrosis Factor-Alpha)人肿瘤坏死因子-α（多肽抗原）
xy-2258xy rh-TNF alpha protein GST Tagged重组人肿瘤坏死因子
xy-0328xy TRA16睾丸激素受体相关蛋白
xy-0884xy rh-IL-1Ra(Recombinant Human Interleukin-1 receptor antagonist His Tag)重组人白介素-1受体拮抗剂
xy-2033xy E.coli DH-5 Alpha(E.coli DH-5 Alpha Protein)DH 5 alpha 大肠杆菌菌体蛋白
xy-0152xy Tranthyretin甲状腺素运载蛋白（抗原）
xy-2050xy rh-EGF(Recombinant Epidermal growth factor)重组人表皮生长因子
xy-0193xy TrK A (h-NGFR) (p140- TrK A)神经生长因子的一种（抗原）
xy-0192xy TrK A.B.C 神经生长因子的一种（抗原） - Stemolecule RG108
- xy-0087xy active Caspase 3(caspase-3 p12 subunit)活化半胱胺酸蛋白酶蛋白-3抗原
xy-2122xy r-GST(Recombinant Glutathione S-T Ahents)重组谷胱甘肽转移酶GST标签蛋白
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