Chemical Name: 4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4- (dimethylamino)-1-phenylsulfanylbutan-2- yl]amino]- 3-nitrophenyl] sulfonylbenzamide
Appearance: Yellow solid
Solubility: Soluble in DMSO (50 mg/ml)
Storage:Store solid at -20 ºC for the stability of two years
储存液配制
储存液 (1 ml DMSO体系)
1 mM
5 mM
10 mM
25 mM
50 mM
质量(mg)
0.8134
4.0672
8.1343
20.3358
40.6715
ABT-737(Bcl-2, Bcl-XL and Bcl-w Inhibitor)结构式
参考文献
[1] Oltersdorf T, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature. 435(7042):677-81 (2005).
[2] Vogler M, et al. Bcl-2 inhibitors: small molecules with a big impact on cancer therapy. Cell Death Differ. 16(3):360-7 (2009).
[3] Konopleva M, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.Cancer Cell. 10(5):375-88 (2006).