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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
1年
- 英文名：
AT-Gap19
- 库存：
30⁺瓶
- 供应商：
上海睿安生物19121878899
- CAS号：
1507930-54-2
- 规格：
1mg/瓶
Tocris货号6227-1mg现货AT-Gap19上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
Purity:≥95%
Biological Activity
TAT-Gap19 is a Cx43 hemichannel blocker(IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription(TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19(Cat. No. 5353).Active in vivo. Brain penetrant
Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
- The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.
Abudara et al.
Front.Cell.Neurosci., 2014;8:1 - Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1.
Freitas-Andrade and Naus
Neuroscience., 2016;323:207
Citations for TAT-Gap19
The citations listed below are publications that use Tocris products. Selected citations for TAT-Gap19 include:
2 Citations: Showing 1 - 2
- Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling.
Authors: Wei Et al.
J Neuroinflammation 2020;17:322 - Connexin 43 gap junctional intercellular communication inhibits evx1 expression and joint formation in regenerating fins.
Authors: Matthias M Et al.
Development 2020;147
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- 内容
- 询问日期
文献和实验Tocris货号6227-1mg现货AT-Gap19上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
Purity:≥95%
Biological Activity
TAT-Gap19 is a Cx43 hemichannel blocker(IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription(TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19(Cat. No. 5353).Active in vivo. Brain penetrant
Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
- The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.
Abudara et al.
Front.Cell.Neurosci., 2014;8:1 - Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1.
Freitas-Andrade and Naus
Neuroscience., 2016;323:207
Citations for TAT-Gap19
The citations listed below are publications that use Tocris products. Selected citations for TAT-Gap19 include:
2 Citations: Showing 1 - 2
- Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling.
Authors: Wei Et al.
J Neuroinflammation 2020;17:322 - Connexin 43 gap junctional intercellular communication inhibits evx1 expression and joint formation in regenerating fins.
Authors: Matthias M Et al.
Development 2020;147
图 UCL（Upper contor limit）=x+A2R=73.25+1.88*2.85=78.10 LCL（Lower contor limit）=x-A2R=67.89 CL（Center limit）=x=73.25 R控制图 UCL=D4R=3.27*2.85=9.32 LCL=D3R=0 Cl=R=2.85 （n为每批检测时应用同浓度质控品的个数） 步骤4.根据一表1及步骤3提供
identification Kit（目录号Sc028）中提供的专用培养基添加剂维持神经祖细胞，并使其向神经谱系分化。利用检测神经前体、星形胶质细胞、神经元和少突胶质细胞的表型特异标志物的抗体分析板（试剂盒中已提供），在功能上验证神经祖细胞的多能性。 关于R&D Systems R&DSystems总公司于1976年成立于美国，在美国NASDAQ上市(TECH)。公司一直致力于各种细胞因子及其相关分子的生产研发。R&D Systems产品覆盖面广，种类丰富，质量稳定可靠
R&D Systems:如何提高MSC的扩增且不损失其分化潜能
。人MSCs （hMSCs ） 购于Cambr e x （ Lonz a ,Walkersville），先根据供应商的说明书培养，然后用StemXVivo人/小鼠骨髓间充质干细胞扩增培养基（ 目录# C C M 0 0 4 ； R & DSystems，Minneapolis）培养。为了测试不同批次FBS的扩增潜能，每种F B S 以终浓度为1 0 % 或2 0 % 加入含有谷氨酰胺， 丙酮酸钠（ I r v i n e S c i e n t i c ， S a n t a A n a ） 的α
