Sigma货号M9281现货3-甲基腺嘌呤(3-Methyl

Sigma货号M9281现货3-甲基腺嘌呤(3-Methyladenine)上海睿安生物13611631389

3-Methyladenine，>98%
【英文同义名】:(3-MA)(NSC 66389)
【中文同义名】:3-甲基腺嘌呤
产品描述
3-Methyladenine(3-MA,NSC 66389)是一种广泛应用的细胞自噬抑制剂，可以抑制PI3K活性，对PI3K Vps34的抑制作用强于PI3Kγ，IC₅₀分别为25μM，60μM。3-Methyladenine以时间和剂量依赖的方式降低细胞活力，其作用与caspase-3的活化相关。在正常和饥饿条件下，3-MA都可以引起肿瘤细胞的死亡，并抑制细胞迁移和侵袭，该作用与其抑制细胞自噬的能力无关。3-MA阻断自噬体的形成，有效抑制细胞内蛋白降解，但是，对细胞内蛋白酶活性没有影响，抑制烟草细胞的细胞自噬反应。
靶点

化学特性

结构式


参考文献
[1] Seglen, et al. 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc. Natl. Acad. Sci. 79(6):1889-92 (1982).
[2] Blommaart EF, et al. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem. 243(1-2):240-6 (1997).
[3] Petiot A,et al. Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells.J Biol Chem. 275(2):992-8 (2000).

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