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Sigma货号E0162-1VL羧基酯酶1异构体c人(别名:
羧酸酯酶1人，羧酸酯酶，酯酶)19121878899上海睿安生物科技有限公司Merck-Roche-Millipore-Sigma官方授权代理商- ￥6026.56
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- E0162-1VL
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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
recombinant,expressed in baculovirus infected BTI insect cells
- 保质期：
1年
- 保存条件：
Dry ice
- 库存：
10⁺支
- 供应商：
上海睿安生物19121878899
- 规格：
1VL/支
Sigma货号E0162-1VL羧基酯酶1异构体c人(别名:羧酸酯酶1人，羧酸酯酶，酯酶)19121878899上海睿安生物科技有限公司Merck-Roche-Millipore-Sigma官方授权代理商
羧基酯酶1异构体c人
recombinant,expressed in baculovirus infected BTI insect cells
别名:羧酸酯酶1人,羧酸酯酶,酯酶
属性
recombinant:expressed in baculovirus infected BTI insect cells
form:liquid
concentration:≥0.3mg/mL
shipped in:dry ice
storage temp:−70°C
Quality Level:200
说明
General description
羧酸酯酶1(CE1)是大型多基因羧酸酯酶α,β水解酶家族的成员。它主要在肝脏中表达。CE1 包括一个 αβ 结构域、一个中心催化结构域和一个调控结构域。该产品的体积为0.5ml。
Application
人羧酸酯酶1亚型c已被用作贻贝羧酸酯酶活性的参考标准，用于比较底物特异性和抑制研究。它还被用作商业重组蛋白，用于基于环境化学的抑制研究的方法验证。
Biochem/physiol Actions
羧酸酯酶负责水解含有酯键和酰胺键的药物，例如可(kǎ)因和海(luò)因。它们还水解长链脂肪酸酯和硫酯。羧酸酯酶1(CE1)催化胆固醇和脂肪酸形成胆固醇酯。通过酯交换反应，CE1 还介导脂肪酸乙酯(FAEE)的产生。它还水解芳族和脂族酯，优先于小的醇基和大的酰基。CE1代谢药物酯类和酰胺类氨基甲酸酯。它参与环境毒物和致癌物的解毒，并可用于评估前药的药代动力学研究。
Other Notes:一个单位是指在pH 7.4、37℃下，每分钟水解1纳摩尔4-硝(jī)苯基乙酸酯所需的酶量
同行评审论文(部分:文献)
The use of an in vitro approach to assess marine invertebrate carboxylesterase responses to chemicals of environmental concern.
Montserrat Solé et al.
Environmental toxicology and pharmacology, 82, 103561-103561 (2020-12-12)
Carboxylesterases (CEs) are key enzymes which catalyse the hydrolysis reactions of multiple xenobiotics and endogenous ester moieties. Given their growing interest in the context of marine pollution and biomonitoring, this study focused on the in vitro sensitivity of marine invertebrate
Human carboxylesterases: a comprehensive review.
Dandan Wang et al.
Acta pharmaceutica Sinica. B, 8(5), 699-712 (2018-09-25)
Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism
Characterisation of plasmatic B-esterases in bottlenose dolphins (Tursiops truncatus) and their potential as biomarkers of xenobiotic chemical exposures.
Sol??, et al.
Environmental Pollution (Barking, Essex : 1987), 313, 120149-120149 (2022)
Carboxylesterases: sources, characterization and broader applications
Sood S, et al.
Insight (American Society of Ophthalmic Registered Nurses), 1, 1-11 (2016)
Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs.
Masakiyo Hosokawa
Molecules (Basel, Switzerland), 13(2), 412-431 (2008-02-29)
Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products play important roles in biotransformation of ester- or amide-type prodrugs. They are members of an alpha,beta-hydrolase-fold family and are found in various mammals. It has been suggested that CESs can
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文献和实验该产品被引用文献
Sigma货号E0162-1VL羧基酯酶1异构体c人(别名:羧酸酯酶1人，羧酸酯酶，酯酶)19121878899上海睿安生物科技有限公司Merck-Roche-Millipore-Sigma官方授权代理商
羧基酯酶1异构体c人
recombinant,expressed in baculovirus infected BTI insect cells
别名:羧酸酯酶1人,羧酸酯酶,酯酶
属性
recombinant:expressed in baculovirus infected BTI insect cells
form:liquid
concentration:≥0.3mg/mL
shipped in:dry ice
storage temp:−70°C
Quality Level:200
说明
General description
羧酸酯酶1(CE1)是大型多基因羧酸酯酶α,β水解酶家族的成员。它主要在肝脏中表达。CE1 包括一个 αβ 结构域、一个中心催化结构域和一个调控结构域。该产品的体积为0.5ml。
Application
人羧酸酯酶1亚型c已被用作贻贝羧酸酯酶活性的参考标准，用于比较底物特异性和抑制研究。它还被用作商业重组蛋白，用于基于环境化学的抑制研究的方法验证。
Biochem/physiol Actions
羧酸酯酶负责水解含有酯键和酰胺键的药物，例如可(kǎ)因和海(luò)因。它们还水解长链脂肪酸酯和硫酯。羧酸酯酶1(CE1)催化胆固醇和脂肪酸形成胆固醇酯。通过酯交换反应，CE1 还介导脂肪酸乙酯(FAEE)的产生。它还水解芳族和脂族酯，优先于小的醇基和大的酰基。CE1代谢药物酯类和酰胺类氨基甲酸酯。它参与环境毒物和致癌物的解毒，并可用于评估前药的药代动力学研究。
Other Notes:一个单位是指在pH 7.4、37℃下，每分钟水解1纳摩尔4-硝(jī)苯基乙酸酯所需的酶量
同行评审论文(部分:文献)
The use of an in vitro approach to assess marine invertebrate carboxylesterase responses to chemicals of environmental concern.
Montserrat Solé et al.
Environmental toxicology and pharmacology, 82, 103561-103561 (2020-12-12)
Carboxylesterases (CEs) are key enzymes which catalyse the hydrolysis reactions of multiple xenobiotics and endogenous ester moieties. Given their growing interest in the context of marine pollution and biomonitoring, this study focused on the in vitro sensitivity of marine invertebrate
Human carboxylesterases: a comprehensive review.
Dandan Wang et al.
Acta pharmaceutica Sinica. B, 8(5), 699-712 (2018-09-25)
Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism
Characterisation of plasmatic B-esterases in bottlenose dolphins (Tursiops truncatus) and their potential as biomarkers of xenobiotic chemical exposures.
Sol??, et al.
Environmental Pollution (Barking, Essex : 1987), 313, 120149-120149 (2022)
Carboxylesterases: sources, characterization and broader applications
Sood S, et al.
Insight (American Society of Ophthalmic Registered Nurses), 1, 1-11 (2016)
Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs.
Masakiyo Hosokawa
Molecules (Basel, Switzerland), 13(2), 412-431 (2008-02-29)
Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products play important roles in biotransformation of ester- or amide-type prodrugs. They are members of an alpha,beta-hydrolase-fold family and are found in various mammals. It has been suggested that CESs can
文献支持
Sigma货号E0162-1VL羧基酯酶1异构体c人(别名:羧酸酯酶1人，羧酸酯酶，酯酶)19121878899上海睿安生物科技有限公司Merck-Roche-Millipore-Sigma官方授权代理商
￥6026.56
