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从原料到标记,打造属于中国自己的流式抗体品牌推荐!临床医学研究优质期刊,覆盖29个领域五大应用案例:Mustang Q 膜层析应用全解析1 个小工具,一次性搞定流程图、质粒图谱和信号通路图- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20℃
- 保质期:
12个月
- 英文名:
Recombinant Inhibitory Subunit Of NF Kappa B Alpha (IkBa)
- 库存:
100
- 供应商:
上海沪震
FOR IN VITRO AND RESEARCH USE ONLY, NOT FOR USE IN CLINICAL DIAGNOSTIC PROCEDURES!
Organism species Homo sapiens (Human)
Product No. RPB848Hu01
Source Prokaryotic expression
Host E.coli
Purity > 95%
UOM 50ug
Predicted Molecular Mass 20.2kDa
Predicted isoelectric point n/a
Applications SDS-PAGE; WB; ELISA; IP.
Endotoxin Level <1.0EU per 1µg (determined by the LAL method)
核因子κB抑制因子α(IκBα)重组蛋白
Subcellular Location n/a
Residues Gly74~Thr247 (Accession # P25963) with N-terminal His-Tag
Formulation Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
SEQUENCES
The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSGSEF-GDSFLHL AIIHEEKALT MEVIRQVKGD LAFLNFQNNL QQTPLHLAVI TNQPEIAEAL LGAGCDPELR DFRGNTPLHL ACEQGCLASV GVLTQSCTTP HLHSILKATN YNGHTCLHLA SIHGYLGIVE LLVSLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG ADVNRVT
USAGE
Reconstitute in sterile PBS, pH7.2-pH7.4.
STORAGE AND STABILITY
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8oC for one month. Aliquot and store at -80oC for 12 months.
Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
About the MARKER (complimentary)
Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and 70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at double intensity to make location and size approximation of proteins of interest quick and easy.
核因子κB抑制因子α(IκBα)重组蛋白Ready-to-use: No need to heat, dilute or add reducing agents before use.
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文献和实验Cell Metab:浙大吕志民团队揭示肿瘤细胞 Warburg 效应促进肿瘤免疫逃逸
2 从线粒体外膜脱落,进入细胞浆中。在细胞浆中,HK2 结合 NF-κB 的抑制因子 IκBα。 重要的是,HK2 发挥了不依赖于其经典代谢功能的新功能,即作为一个蛋白激酶磷酸化 IκBα 的 Thr 291 位点。该磷酸化促进了蛋白酶 μ-calpain 与 IκBα 的结合并进一步降解 IκBα,进而使转录因子 NF-κB 入核,最终促进了 PD-L1 的表达并导致了肿瘤的免疫逃逸。作者还发现,使用己糖激酶的抑制剂与 PD-1 抗体联用治疗小鼠胶质瘤,可以显著提升 PD-1 抗体的治疗
OLR1(LOX-1)配体结合机制、胞内信号调控及蛋白试剂应用解析
的信号通路和调控 当氧化低密度脂蛋白(Ox-LDL)与LOX-1受体结合后,会触发一系列复杂的细胞内信号级联反应,从根本上改变细胞的生理状态。首先,这种结合会导致细胞内活性氧(ROS)水平显著升高,同时抑制一氧化氮(NO)的正常释放。这种氧化应激环境不仅直接损伤细胞,还激活了PI3K/AKT/GSK3β这一关键信号通路。 随之而来的是转录层面的剧烈变化。上述信号通路共同作用,激活了NF-κB以及上皮-间充质转化(EMT)相关的转录因子。NO的减少进一步加剧了炎症反应,促使IL-6、IL-8和IL
+ TPD 新药转化 泛素化之所以持续成为热点,不仅因为其生物学功能复杂,更因为它正在推动疾病机制研究和创新药研发。当前最受关注的主要集中在以下两个方向: 1、泛素通路失衡:各类疾病发病的核心调控机制 泛素通路稳态失衡是重大疾病发生的核心底层机制。肿瘤中,USPs等去泛素化酶异常活化,通过去泛素化稳定MYC、p53等关键蛋白,驱动肿瘤增殖、转移与化疗耐药;神经退行性疾病中,蛋白酶体功能缺陷导致tau蛋白、α-突触核蛋白等错误折叠蛋白大量蓄积,产生神经毒性;自身免疫病中,泛素化紊乱持续激活NF-κB通路
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