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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20℃
- 保质期:
12个月
- 英文名:
Recombinant Insulin Like Growth Factor 1 Receptor (IGF1R)
- 库存:
100
- 供应商:
上海沪震
FOR IN VITRO AND RESEARCH USE ONLY, NOT FOR USE IN CLINICAL DIAGNOSTIC PROCEDURES!
Organism species Homo sapiens (Human)
Product No. RPB659Hu01
Source Prokaryotic expression
Host E.coli
Purity > 95%
UOM 50ug
Predicted Molecular Mass 25.8kDa
Predicted isoelectric point 5.9
Applications SDS-PAGE; WB; ELISA; IP.
Endotoxin Level <1.0EU per 1µg (determined by the LAL method)
胰岛素样生长因子1受体(IGF1R)重组蛋白
Subcellular Location Cell membrane; Single-pass type I membrane protein
Residues Tyr763~Leu955 (Accession # P08069) with two N-terminal Tags, His-tag and T7-tag
Formulation Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
SEQUENCES
The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- YNITDPEE LETEYPFFES RVDNKERTVI SNLRPFTLYR IDIHSCNHEA EKLGCSASNF VFARTMPAEG ADDIPGPVTW EPRPENSIFL KWPEPENPNG LILMYEIKYG SQVEDQRECV SRQEYRKYGG AKLNRLNPGN YTARIQATSL SGNGSWTDPV FFYVQAKTGY ENFIHLIIAL PVAVLLIVGG LVIML
USAGE
Reconstitute in sterile PBS, pH7.2-pH7.4.
STORAGE AND STABILITY
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8oC for one month. Aliquot and store at -80oC for 12 months.
Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage 胰岛素样生长因子1受体(IGF1R)重组蛋白condition.
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文献和实验症综合征的遗传热点。由于WAPCre系统,这种点突变只在小鼠的乳腺中活跃,通过这种突变,该菌株将在1岁左右自发地发展出与人类相关的乳腺肿瘤。我们经常让这些小鼠模型接触胰岛素样分子。频繁注射两种模型化合物AspB10和胰岛素样生长因子-1(IGF1)后,大鼠乳腺肿瘤的表达明显降低。AspB10,又称X10,是一种早期胰岛素类似物,由于增强了IGF1R结合亲和力,具有很强的启动细胞分裂的潜力。IGF1是IGF1R的天然配体,这种受体在细胞分裂信号中起着重要作用。与常规胰岛素相比,甘精胰岛素在体外实验中
-1的稳定性和可溶性,是人胰岛素生长因子的重组类似物。类胰岛素生长因子-1(IGF-1)是一种分子量为7.6kD的激素,其分子结构与胰岛素类似。IGF-1的主要作用机理是通过与其特异性受体(IGF1R)结合来诱导细胞内的信号传导。IGF-1是AKT信号通路的最有效的激活因子之一,激活AKT信号通路后,刺激细胞生长及增殖,并抑制细胞凋亡。因此,IGF-1被广泛视为胰岛素的强有力替代品。IGF-1与人血清白蛋白融合表达,形成了分子量约为74.5kD的融合蛋白OsrIGF-1,使得OsrIGF-1半衰期更长
的点突变而得名;一种与人类李弗罗梅尼癌症综合征基因热点相对应的基因。由于WAPCre系统,该位点突变只在小鼠乳腺中活跃,在1岁左右,该菌株会自发地发展为人类相关乳腺肿瘤。我们经常将这些小鼠模型暴露在类胰岛素分子中。频繁注射两种模型化合物AspB10和胰岛素样生长因子-1 (IGF1)后,肿瘤表达明显下降,这两种模型化合物均与大鼠乳腺肿瘤相关。AspB10,也被称为X10,是一种早期的胰岛素类似物,由于增强了IGF1R的结合亲和力,具有启动细胞分裂的强大潜力。IGF1是IGF1R的天然配体,该受体在细胞
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