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- HCV-265
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- 2025年07月08日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 英文名：
Hepatitis C Virus NS3 Genotype-2c, (1356-1459 a.a.) Recombinant
- 保质期：
1年
- 供应商：
上海沪震实业有限公司
- 保存条件：
-20°C
- 规格：
100µg/500µg/1000µg
CATALOGUE NUMBER
HCV-265
INTRODUCTION
HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae.HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).
DESCRIPTION
The E.coli derived recombinant protein contains the HCV NS3 immunodominant regions, amino acids 1356-1459.PURIFICATION METHOD
HCV NS3 Genotype-2c protein was purified by proprietary chromatographic technique.PURITY
HCV NS3 Genotype-2c protein is >95% pure as determined by 10% PAGE (coomassie staining).FORMULATION
1.5M urea, 25mM Tris-HCl pH-8, 0.2% Triton-X & 50% Glycerol.STABILITY
HCV NS3 Genotype-2c although stable at 4°C for 1 week, should be stored below -18°C.
Please prevent freeze thaw cycles.
SPECIFICITY
Immunoreactive with sera of HCV-infected individuals.APPLICATIONS
HCV NS3 Genotype-2c antigen is suitable for ELISA and Western blots, excellent antigen for detection of HCV with minimal specificity problems.USAGE
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Expression and Characterization of HCV NS3 Protease
The overexpression of a gene in a heterologous system is often the prelude to or the prerequisite of the elucidation and characterization of a given protein, in particular where the protein is difficult to obtain in sufficient quantity
Expression and Characterization of the HCV NS3 Helicase Domain
The hepatitis C virus (HCV) NS3 protein has two distinct biochemical domains. The N-terminal 20 kDa has serine protease activity (see Chapter 31 ) and the C-terminal 50 kDa has both nucleoside triphosphatase (NTPase) and helicase activities
Genotype 1a HCV (H77S) Infection System
therapy, based on the use of interferon-α (IFN-α) in combination with ribavirin, results in limited success, especially in patients infected with the most prevalent genotype 1 viruses. Better therapies are needed, but the inability to propagate HCV in cell
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