α-连环蛋白抗体（α链接素）

α-连环蛋白抗体（α链接素）产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

α-连环蛋白抗体（α链接素）产品介绍

细胞粘附蛋白（Call Adhesion Protein）
α-catenin是一种多功能的蛋白质，能链接E-\N-\P-钙粘附分子,具有参与细胞粘附和介导信号转导的双重功能，并与肿瘤的发生发展及浸润密切相关。
在正常个体中，βα-catenin和钙黏蛋白形成复合体，介导同型细胞的粘附，维持细胞的稳定；同时，α-catenin作为Wnt/α-catenin信号通路的关键成员在介导信号转导过程中调控细胞的增殖和凋亡。
在恶性肿瘤中，α-catenin的表达呈现明显的异质性，促使细胞异常增殖，还可使细胞之间的黏附性减弱，侵袭性增强。
The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
Also known as:
alpha catenin ; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadherin associated protein; CAP 102; CAP102; Catenin (cadherin associated protein) alpha 1 102kDa; Catenin alpha 1; CTNNA 1; CTNNA1; FLJ36832; NY REN 13 antigen

α-连环蛋白抗体（α链接素）其它产品：yb-11023R DNAH7轴丝动力蛋白7抗体
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yb-11431R DUOX1双氧化酶1/甲状腺氧化酶1抗体
yb-11432R DUOX2双氧化酶2/甲状腺氧化酶2抗体
yb-11433R DUOXA1双氧化酶成熟因子抗体
yb-11825R DOCK7胞质分裂专一蛋白7抗体
yb-6376R DDIT4LDNA损伤诱导转录样蛋白4抗体
yb-7625R DAP3死亡相关蛋白3抗体
yb-7129R Defensin alpha 6防御素α6抗体
yb-5748R DBF4BS期激酶活化蛋白DBF4B抗体
yb-5749R DCK脱氧胞苷激酶抗体
yb-2286R DHRS3短链脱氢还原酶3抗体
yb-13022R DNA Polymerase theta/POLHDNA聚合酶θ/DNA pol θ抗体
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yb-4075R phospho-DAG1 (Tyr892)磷酸化肌萎缩相关蛋白DAG1抗体
yb-5303R phospho-DAAM1 (Thr361)磷酸化形态发生紊乱关联激活因子1抗体
yb-5290R phospho-DOK1 (Tyr398)磷酸化D酪氨酸激酶衰减蛋白1抗体
yb-5288R phospho-DAXX (Ser213)磷酸化Fas相关死亡结构域蛋白抗体
yb-5289R phospho-DOK1(Tyr362)磷酸化D酪氨酸激酶衰减蛋白1抗体
yb-5291R phospho-DAXX (Ser495)磷酸化Fas相关死亡结构域蛋白抗体
yb-5292R phospho-DAXX (Ser517)磷酸化Fas相关死亡结构域蛋白抗体
yb-5293R phospho-DAXX (Ser671)磷酸化Fas相关死亡结构域蛋白抗体