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| 规格： | 10 mM * 1 mL | 产品价格： | ￥1257.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥439.0 |
| 规格： | 2 mg | 产品价格： | ￥740.0 |
| 规格： | 5 mg | 产品价格： | ￥1180.0 |
| 规格： | 10 mg | 产品价格： | ￥1963.0 |
| 规格： | 25 mg | 产品价格： | ￥3432.0 |
| 规格： | 50 mg | 产品价格： | ￥5153.0 |
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FTI-277 hydrochloride
CAS No. : 180977-34-8
MCE 国际站：FTI-277 hydrochloride
产品活性：FTI-277 hydrochloride 是法尼基转移酶 FTase 抑制剂，高效 Ras CAAX 肽模拟物，可抑制 H-Ras 和 K-Ras 信号转导。FTI-277 hydrochloride 可抑制 hepatitis delta virus (HDV) 感染。
研究领域：Metabolic Enzyme/Protease | Apoptosis | GPCR/G Protein
作用靶点：Farnesyl Transferase | Apoptosis | Ras
In Vitro: Treatment with FTI-277 (20 microM) for 48 h prior to irradiation led to a significant decrease in survival of radioresistant cells expressing the 24-kDa isoform (HeLa 3A) but had no effect on the survival of control cells (HeLa PINA). The radiosensitizing effect of FTI-277 is accompanied by a stimulation of postmitotic cell death in HeLa 3A cells and by a reduction in G(2)/M-phase arrest in both cell types [1]. Treatment of PC-3 cells with GGTI-298 and FTI-277 inhibited migration and invasion in a time- and dose-dependent manner [3].
In Vivo: FTI-277 treatment prevented increased PTP-1B and PTEN protein expression in burned mice as compared with vehicle alone. In contrast, FTI-277 did not significantly alter protein expression of PTP-1B and PTEN in sham-burned mice [2].
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文献和实验AAGGGAAAGAAGGAGGUUUCA RBL-2H3, WEHI-231, NALM-6 Bruton's tyrosine kinase (Btk) (33) NM_000061 518-536 AAGAAGCUUAAAACCUGGGAG RBL-2H3, WEHI-231, NALM-6 Casein Kinase I epsilon and delta (CKI-epsilon and CKI-delta) (17) 520-538 AACUGGGGAAGAAGGGCAACC HEK293 Caspase 1 (34
and CKI-delta) (17) 520-538 AACUGGGGAAGAAGGGCAACC HEK293 View, Order View Caspase 1 (34) 191-211 AAGGGGCACAGGCATGCCAAA IMR90E1A View, Order View Caspase 2 (34) 94-114
【求助】microRNA106-b~25的~25，是什么意思？
Dreyfuss, Sean R. Eddy, Sam Griffiths-Jones, Mhairi Marshall, Marjori Matzke, Gary Ruvkun, and Thomas Tuschl. A uniform system for microRNA annotation. RNA 2003 9(3):277-279. http://www.mirbase.org/help/nomenclature.shtml myskite
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