Dkk3 / REIC抗体

Dkk3 / REIC抗体产品信息

免疫原 :
Recombinant human Dkk3 protein ( Catalog#10203-H08H )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human Dkk3 ( rhDkk3; Catalog#10203-H08H; aa 1 - 350; NP_001018067.1 ). Dkk3 specific IgG was purified by human Dkk3 affinity chromatography.
Dkk3 / REIC抗体 Background
Dkk3, also known as REIC (Reduced Expansion in Immortalized Cells), is a member of the dickkopf-related family which has distinct patterns of expression in adult and embryonic tissues. Dkk3 is a secreted protein with two cysteine-rich domains separated by a linker region, and has a wide range of effects on tissue development and morphogenesis through its interactions with the Wnt signaling pathway. The expression of Dkk3 gene is down regulated in human immortalized cells and a variety of tumors, such as hepatoma, lung carcinomas and malignant melanoma. Meanwhile, overexpression of Dkk3 results in tumor cell line-specific growth inhibition and apoptosis. Dkk3 may function as a suppressor gene of tumor growth and be regarded as a promising potential therapeutic target.
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