IL1R3 / IL1RAP抗体

IL1R3 / IL1RAP抗体产品信息

免疫原 :
Recombinant human IL1R3 protein ( Catalog#10121-H08H )
抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
7E4G1E8
抗体宿主 :
Mouse IgG2a
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human IL1R3 / IL1RAP ( rh IL1R3 ; Catalog#10121-H08H ; NP_002173.1 ; Met 1 - Glu 359 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
IL1R3 / IL1RAP抗体背景综述
IL-1 receptor accessory protein (IL-1RAcP), also called as IL1R3, is identified as a subunit of membrane-bound form of the IL-1 receptor. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. Two alternative splice variants of IL-1RacP have been identified: membrane-bound IL-1RAcP (mIL-1RAcP) promotes intracellular IL-1 signalling whereas soluble IL-1RAcP (sIL-1RAcP) contributes to the antagonism of IL-1 action by the type II decoy receptor, adding another layer of complexity to the regulation of IL-1 action. As an indispensible molecule in the IL-1 receptor signal transduction, IL-1RAcP is necessary to link events on the plasma membrane level to downstream signaling pathways. The intracellular signaling of IL-1 mediated by the membrabe receptor involves formation of a ternary receptor complex containing IL1RAcP, IL1R1, adapter protein MyD88, and IL-1R-associated kinases IRAK1 or IRAK2 which is capable of associating directly with either IL1R1 or IL1RacP. Subsquently, multiple cellular responses are generated including NF-κB activation, IL-2 secretion, and IL-2 promoter activation.
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