ALCAM / CD166抗体

ALCAM / CD166抗体产品信息

免疫原 :
Recombinant mouse ALCAM protein ( Catalog#50005-M08H )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse ALCAM / CD166 extracellular domain ( rM ALCAM ; Catalog#50005-M08H ; NP_033785.1 ; Met 1 - Lys 527 ). Total IgG was purified by Protein A affinity chromatography
ALCAM / CD166抗体背景综述
Mouse ALCAM (activated leukocyte cell adhesion molecule) is a type I membrane glycoprotein and a member of the immunoglobulin superfamily. It is also known as CD166, MEMD, SC-1/DM-GRASP in the chicken, and KG-CAM in the rat. Mouse ALCAM is a 583 amino acid protein consisting of a 27 aa signal peptide, a 500 aa extracellular domain, a 24 aa transmembrane domain and a 32 aa cytoplasmic domain. The extracellul 27 aa signal peptide, a 500 aa extracellular domain, a 24 aa transmembrane ar domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains),of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. Mouse ALCAM is expressed at high levels in the brain and lung, and at lower levels in the liver and the kidney, as well as by activated leukocytes and a number of cell lines. ALCAM can bind itself homotypically and is also capable of binding CD6, NgCAM, and other unidentified brain proteins, and thus is Involved in neurite extension by neurons via heterophilic and homophilic manners. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Further, ALCAM has also been observed to be upregulated on highly metastasizing melanoma cell lines, suggesting a role in tumor migration.
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