CD166 / ALCAM抗体

CD166 / ALCAM抗体产品信息免疫原 : Recombinant Human CD166 / ALCAM protein (Catalog#10045-H08H)

Reagents : FITC-conjugated mouse monoclonal antibody
Clone ID : 03
抗体宿主 : Mouse IgG1
Concentration : 5 μl/Test, 0.2 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD166 / ALCAM (rh CD166 / ALCAM; Catalog#10045-H08H; NP_001618.2; Met 1-Ala 526) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
CD166 / ALCAM抗体 Background
ALCAM (activated leukocyte cell adhesion molecule) is a type I membrane glycoprotein and a member of the immunoglobulin superfamily. It is also known as CD166, MEMD, SC-1/DM-GRASP in the chicken, and KG-CAM in the rat. ALCAM / CD166 has five extracellular immunoglobulin-like domains which facilitates heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. While expressed in a wide variety of tissues and cells, ALCAM is restricted to subsets of cells usually involved in dynamic growth and / or migration processes. ALCAM is highly associated not only with embryonic hematopoiesis but also vasculoangiogenesis. ALCAM can bind itself homotypically and is also capable of binding CD6, NgCAM, and other unidentified brain proteins, and thus is Involved in neurite extension by neurons via heterophilic and homophilic manners. ALCAM / CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- cells and B-cells to activated leukocytes. Further, ALCAM has also been observed to be upregulated on highly metastasizing melanoma cell lines, suggesting a role in tumor migration.
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