CD46抗体

CD46抗体产品信息

免疫原 :
Recombinant Human CD46 protein (Catalog#12239-H08H)
Reagents : FITC-conjugated mouse monoclonal antibody
Clone ID :
05
抗体宿主 :
Mouse IgG1
Concentration :
5 μl/Test, 0.2 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD46 (rh CD46; Catalog#12239-H08H; EAW93471.1; Met 1-Asp 328) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
CD46抗体 Background
CD46 complement regulatory protein, also known as membrane cofactor protein, Trophoblast leukocyte common antigen, is a single-pass type I membrane protein which contains fourSushi (CCP/SCR) domains. CD46 is a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. CD46 is expressed by all cells except erythrocytes. CD46 acts as a cofactor for complement factor I. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2) which is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea.
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