CEACAM3 / CD66d抗体

CEACAM3 / CD66d抗体产品信息

免疫原 :
Recombinant Human CEACAM3 / CD66d protein (Catalog#11933-H08H)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
5D1A2
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CEACAM3 / CD66d (rh CEACAM3 / CD66d; Catalog#11933-H08H; NP_001806.2; Met 1-Gly 155). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CEACAM3 / CD66d抗体 Background
Carcinoembryonic antigen-related cell adhesion molecule 3, also known as Carcinoembryonic antigen CGM1, CEACAM3 and CD66D, is a single-pass type I membrane protein which belongs to theimmunoglobulin superfamily and CEA family. There are two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, and seven CEACAM has been identified in humans including type I transmembrane proteins (CEACAM-1, CEACAM-3, CEACAM-4) and GPI-linked molecules (CEACAM-5, CEACAM-8). The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses. CEACAM3 / CD66D is a major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species. It plays an important role in the clearance of pathogens by the innate immune system. CEACAM3 / CD66D is responsible for RAC1 stimulation in the course of pathogen phagocytosis.
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