IL-1 beta / IL-1B Antibody

IL-1 beta / IL-1B Antibody Product Information

免疫原 :
Recombinant human ILb protein ( Catalog#10139-HNAE )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, E.coli-derived, recombinant human IL1B ( rh IL1B ; Catalog#10139-HNAE ; NP_000567.1 ; Ala 117 - Ser 269 ). IL1B specific IgG was purified by human IL1B affinity chromatography.
IL-1 beta / IL-1B Antibody背景综述
Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1alpha (IL-1F1) and IL-1beta (IL-1F2) encoded by two distinct genes and perform identical biological functions . IL1α and IL1β binds directly to a high-affinity receptor complex of IL1 RI and IL1 R AcP to initiate the signal transduction. IL1RII also binds to IL1β with high affinity, but on contrast, IL1β activity is inhibited since IL1RII exists as a decoy receptor and negative regulator.IL1R antgonist (IL1RA), also a member of IL-1 family, is identified to interact with IL1R1, preventing IL1α and IL1β to exert actions. IL1β is produced by a variety of cell types, and capable of stimulating thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. Also identified as endogenous pyrogens, IL-1 are involved in the immune and inflammatory responses, and are reported to stimulate the release of prostaglandin and collagenase. IL1β is encoded as a inactive precusor of 269 amino acids with a 116 aa propeptide which is cleaved intracellularly by the cysteine protease, IL1β converting enzyme (Caspase1/ICE) to generate the biologically active cytokine. Lacking of a specific hydrophobic segment suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
IL-1 beta / IL-1B Antibody相关产品如下：
hz-12552R Phospho-Aurora B(Tyr12)磷酸化有丝分裂激酶B抗体
hz-12529R ARPM1肌动蛋白相关蛋白M1抗体
hz-12565R ABH1ALKB蛋白抗体
hz-12566R ACAA1乙酰辅酶A酰基转移酶1抗体
hz-12581R phospho-beta Actin (Tyr53)磷酸化β-肌动蛋白抗体
hz-12978R phospho-beta 2 Adrenergic Receptor (Ser346)磷酸化肾上腺素能受体β2/β2-AR 抗体
hz-12979R phospho-beta 2 Adrenergic Receptor (Ser355 + Ser356)磷酸化肾上腺素能受体β2/β2-AR抗体
hz-10130R APOD载脂蛋白D抗体
hz-2586R ASIC1/BNaC2/ASIC1A酸敏感离子通道1抗体
hz-2168R ADAR1 (C-terminus)双链RNA腺苷酸脱氨基酶抗体（C端）
hz-3696R AF10髓系、淋巴、混合系白血病易位基因10抗体
hz-3681R ADCY1腺苷酸环化酶1抗体
hz-3680R APC腺瘤样息肉抗体
hz-5023R AGPAT1溶血磷脂酰基转移酶抗体
hz-9098R ANKS3锚蛋白重复及SAM结构域蛋白3抗体
hz-3047R phospho-ALK (Tyr1586)磷酸化间变型淋巴瘤激酶抗体
hz-5018R ACADVL酰基辅酶A脱氢酶很长链抗体
hz-7735R AMSH信号转导衔接结合蛋白抗体
hz-7736R ASB3锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体
hz-2750R Aurora C有丝分裂激酶B抗体
hz-3045R Phospho-Ack1 (Tyr284)磷酸化Ack1抗体
hz-3046R Phospho-Ack1 (Tyr326)磷酸化Ack1抗体
hz-3048R Phospho-beta-Arrestin 1 (Ser412)磷酸化β抑制蛋白1抗体
hz-3050R Phospho-Aurora A (Thr288)磷酸化有丝分裂激酶A抗体
hz-3003R phospho-APS(Ser598)磷酸化APS抗体
hz-2749R Aurora A有丝分裂激酶A抗体
hz-5986R AIM2干扰素诱导蛋白AIM2抗体
hz-4611R Aquaporine 2水通道蛋白-2抗体
hz-5984R ABI2肿瘤抑制基因ABI2/精氨酸酪氨酸蛋白激酶结合蛋白抗体
hz-5987R ARL11ADP核糖基化因子样11抗体
hz-5990R ARMCX3ARM重复X连锁蛋白ARMCX3抗体
hz-5988R ARMCX1ARM重复X连锁蛋白ARMCX1抗体
hz-5989R ARMCX2ARM重复X连锁蛋白ARMCX2抗体
hz-5991R Apg10自噬相关蛋白10抗体
hz-6017R ACBD6酰基辅酶A结合结构域蛋白6抗体
hz-6019R Aminoacylase 1氨基酰化酶1抗体
hz-3831R Adipose Triglyceride Lipase脂肪甘油三酯脂酶抗体
hz-4002R phospho-AMPK alpha-1 (Thr172)磷酸化腺苷单磷酸活化蛋白激酶α1抗体
hz-3847R Amphiregulin双调蛋白（结肠直肠细胞源性生长因子）抗体
hz-5185R phospho-AQP2(Ser264)磷酸化水通道蛋白2抗体