IL-1 beta / IL-1B抗体

IL-1 beta / IL-1B抗体产品信息免疫原 : Recombinant human ILb protein ( Catalog#10139-HNAE )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, E.coli-derived, recombinant human IL1B ( rh IL1B ; Catalog#10139-HNAE ; NP_000567.1 ; Ala 117 - Ser 269 ). Total IgG was purified by Protein A affinity chromatography.
IL-1 beta / IL-1B抗体背景综述
Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1alpha (IL-1F1) and IL-1beta (IL-1F2) encoded by two distinct genes and perform identical biological functions . IL1α and IL1β binds directly to a high-affinity receptor complex of IL1 RI and IL1 R AcP to initiate the signal transduction. IL1RII also binds to IL1β with high affinity, but on contrast, IL1β activity is inhibited since IL1RII exists as a decoy receptor and negative regulator.IL1R antgonist (IL1RA), also a member of IL-1 family, is identified to interact with IL1R1, preventing IL1α and IL1β to exert actions. IL1β is produced by a variety of cell types, and capable of stimulating thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. Also identified as endogenous pyrogens, IL-1 are involved in the immune and inflammatory responses, and are reported to stimulate the release of prostaglandin and collagenase. IL1β is encoded as a inactive precusor of 269 amino acids with a 116 aa propeptide which is cleaved intracellularly by the cysteine protease, IL1β converting enzyme (Caspase1/ICE) to generate the biologically active cytokine. Lacking of a specific hydrophobic segment suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
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